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(2005). https://pubmed.ncbi.nlm.nih.gov/15623839/ DOI: 10.1093/jn/135.1.92","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Duodenal enterocytes and whole-body iron","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"24ed6aba-1d83-5778-bbcf-8dcb99145d8a","evidence_kind":"source_excerpt","locator":"Lines 858-869","start_line":858,"end_line":869,"excerpt":"### copper-cud-hephaestin\nCopper-deficient rats had enterocyte hephaestin protein at about 35% of copper-adequate controls.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Copper shortage reduced part of the intestine’s iron-processing machinery.\norganism: Rat\ntissue_or_cell_type: Duodenal enterocytes and whole-body iron\nexperimental_model: Controlled copper-deficient versus adequate diets with radiolabeled iron\nlimitations: Animal depletion regimens are not human thresholds. Iron redistribution differed by sex.\nexposure: Less than 0.3 versus 5 mg copper/kg diet; male and female weanlings\nevidence_span: {\"source_cache\": \"artifacts/copper-research/15623839.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5e3723e4fdd961caf66979e26614d98cbfbd65f38ba48232428e5302c054c3ac\", \"start_char\": 0, \"end_char\": 1613, \"text_sha256\": \"5e3723e4fdd961caf66979e26614d98cbfbd65f38ba48232428e5302c054c3ac\"}\n[copper-p15623839] Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. (2005). https://pubmed.ncbi.nlm.nih.gov/15623839/ DOI: 10.1093/jn/135.1.92","model_system":"Controlled copper-deficient versus adequate diets with radiolabeled iron","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p15623839] Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. (2005). https://pubmed.ncbi.nlm.nih.gov/15623839/ DOI: 10.1093/jn/135.1.92","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}