{"id":"c30afc2e-e3ff-5574-90cf-957b259aedc6","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-human-free-null","predicate":"no_detectable_parent","statement":"The sensitive 2011 assay did not detect free 8-gingerol in plasma after the 2 g ginger dose.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"bf773b8e-7a8d-5d32-83c3-5ae4566fc0e9","mechanism_event_label":"The sensitive 2011 assay did not detect free 8-gingerol in plasma after the 2 g ginger dose.","subject":{"id":"000525c3-a599-5da3-98a9-d70875a53a6d","slug":"ginger-2011-pk-preparation","display_name":"Ginger extract in the 2011 human pharmacokinetic study","entity_type_key":"small_molecule"},"object":{"id":"cf945af6-c38b-535a-af82-fc8f5cf8fc34","slug":"human-plasma-free-8-gingerol","display_name":"Unconjugated 8-gingerol in human plasma","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bf773b8e-7a8d-5d32-83c3-5ae4566fc0e9","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-human-free-null-event","event_type":"observed_relationship","label":"The sensitive 2011 assay did not detect free 8-gingerol in plasma after the 2 g ginger dose.","description":"The sensitive 2011 assay did not detect free 8-gingerol in plasma after the 2 g ginger dose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"000525c3-a599-5da3-98a9-d70875a53a6d","slug":"ginger-2011-pk-preparation","display_name":"Ginger extract in the 2011 human pharmacokinetic study","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cf945af6-c38b-535a-af82-fc8f5cf8fc34","slug":"human-plasma-free-8-gingerol","display_name":"Unconjugated 8-gingerol in human plasma","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Ginger extract 2 g; LC-MS/MS lower quantification limit 2-5 ng/mL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Sampling 0.25-24 h for parent analytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Food/product and analytical sensitivity differ from the 2008 study. 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(2011). https://pubmed.ncbi.nlm.nih.gov/21638149/ DOI: 10.1208/s12248-011-9286-5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral mixed ginger extract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e33f891d-0252-5591-9079-d9f6b235275a","evidence_kind":"source_excerpt","locator":"Lines 393-402","start_line":393,"end_line":402,"excerpt":"## gingerols-8-human-free-null\nThe sensitive 2011 assay did not detect free 8-gingerol in plasma after the 2 g ginger dose.\nModel/species: Healthy human volunteers\nTissue: Plasma\nExposure: Ginger extract 2 g; LC-MS/MS lower quantification limit 2-5 ng/mL\nRoute: Oral mixed ginger extract\nDuration: Sampling 0.25-24 h for parent analytes\nLimits: Food/product and analytical sensitivity differ from the 2008 study. 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