{"id":"c23e458d-34c2-5b68-878c-64337a37d3b4","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-ct2-transport","predicate":"transports","statement":"Human CT2 expressed in Xenopus oocytes mediated high-affinity carnitine transport; tissue staining located CT2 in epididymal luminal membranes and Sertoli cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6e382791-62ee-58b6-91ed-cb47fafe5920","mechanism_event_label":"A distinct transporter connects carnitine with the reproductive tract.","subject":{"id":"88617a4e-9f0f-5aaf-a0ae-23226d722fd3","slug":"human-slc22a16","display_name":"Human carnitine transporter CT2 / SLC22A16","entity_type_key":"protein"},"object":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"6e382791-62ee-58b6-91ed-cb47fafe5920","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-ct2-transport-event","event_type":"observed_relationship","label":"A distinct transporter connects carnitine with the reproductive tract.","description":"Human CT2 expressed in Xenopus oocytes mediated high-affinity carnitine transport; tissue staining located CT2 in epididymal luminal membranes and Sertoli cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"88617a4e-9f0f-5aaf-a0ae-23226d722fd3","slug":"human-slc22a16","display_name":"Human carnitine transporter CT2 / SLC22A16","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human transporter cloning, oocyte transport and tissue immunohistochemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transport/localization do not establish improved fertility from carnitine supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A distinct transporter connects carnitine with the reproductive tract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12089149/ · DOI 10.1074/jbc.M203883200","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"High-affinity carnitine transport measured in expressing oocytes.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"High-affinity carnitine transport measured in expressing oocytes.","entity":null}],"evidence":[{"id":"6442b2b9-396b-598b-a2bc-4a045af313b0","evidence_kind":"source_excerpt","locator":"Lines 482-488","start_line":482,"end_line":488,"excerpt":"## l-carnitine-ct2-transport\nA distinct transporter connects carnitine with the reproductive tract.\nHuman CT2 expressed in Xenopus oocytes mediated high-affinity carnitine transport; tissue staining located CT2 in epididymal luminal membranes and Sertoli cells.\nModel: Human transporter cloning, oocyte transport and tissue immunohistochemistry.\nLimitations: Transport/localization do not establish improved fertility from carnitine supplements.\nEvidence access: Primary abstract\nMolecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12089149/ · DOI 10.1074/jbc.M203883200","model_system":"Human transporter cloning, oocyte transport and tissue immunohistochemistry.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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