{"id":"c20918ef-fc51-5560-b23d-19283688c13e","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-l6-glucose","predicate":"increases","statement":"Adding (S)-6-gingerol increased glucose uptake in rat L6 myotubes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"f0097276-0d69-5e62-b6a6-b7d181a2bb00","mechanism_event_label":"Adding (S)-6-gingerol increased glucose uptake in rat L6 myotubes.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"b6ecad8e-71de-5e96-a89e-aba452579d4e","slug":"rat-myotube-glucose-uptake","display_name":"Rat myotube glucose uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f0097276-0d69-5e62-b6a6-b7d181a2bb00","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-l6-glucose-event","event_type":"observed_relationship","label":"Adding (S)-6-gingerol increased glucose uptake in rat L6 myotubes.","description":"Adding (S)-6-gingerol increased glucose uptake in rat L6 myotubes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6ecad8e-71de-5e96-a89e-aba452579d4e","slug":"rat-myotube-glucose-uptake","display_name":"Rat myotube glucose uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"378e97ad-f6dc-5b66-a889-e95543049489","slug":"rat-ampk-complexes","display_name":"Rat AMP-activated protein kinase complexes","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"(S)-6-Gingerol; dose-response, exact range not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Time-dependent response; exact times not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat L6 skeletal muscle myotubes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Calcium/CaMKK-associated signaling does not demonstrate dietary calcium depletion or calcium-supplement synergy; no human glycemic outcome was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat L6 skeletal muscle myotubes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding (S)-6-gingerol increased glucose uptake in rat L6 myotubes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"(S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i. (2013). https://pubmed.ncbi.nlm.nih.gov/23958199/ DOI: 10.18433/j34g7p","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Skeletal muscle cell model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"77f33dab-2713-5afa-aa13-b8bee16070e7","evidence_kind":"source_excerpt","locator":"Lines 173-182","start_line":173,"end_line":182,"excerpt":"## gingerols-6-l6-glucose\nAdding (S)-6-gingerol increased glucose uptake in rat L6 myotubes.\nModel/species: Rat L6 skeletal muscle myotubes\nTissue: Skeletal muscle cell model\nExposure: (S)-6-Gingerol; dose-response, exact range not in accessed abstract\nRoute: In vitro addition\nDuration: Time-dependent response; exact times not in accessed abstract\nLimits: Calcium/CaMKK-associated signaling does not demonstrate dietary calcium depletion or calcium-supplement synergy; no human glycemic outcome was tested.\nPrimary reference: (S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i. (2013). https://pubmed.ncbi.nlm.nih.gov/23958199/ DOI: 10.18433/j34g7p\nAccess: Primary PubMed abstract.","model_system":"Rat L6 skeletal muscle myotubes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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