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The enzyme-inhibition arm tested capsaicin, not dihydrocapsaicin, which is recorded on that claim.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dihydrocapsaicin","display_name":"Dihydrocapsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The parent compound jams the liver’s drug-clearing machinery; its hydroxylated product does not.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dhc-p8614248] Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications. (1995). https://pubmed.ncbi.nlm.nih.gov/8614248/ DOI: 10.1016/0024-3205(95)00091-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5c5105d1-7a23-5518-be9b-160f6db38c53","evidence_kind":"source_excerpt","locator":"Lines 543-554","start_line":543,"end_line":554,"excerpt":"### dhc-capsaicin-inhibits-enzymes\nCapsaicin interacted irreversibly with hepatic drug metabolizing enzymes, thereby inhibiting their activity as indicated by prolongation of pentobarbital sleeping time in rats, and such inhibition of drug metabolism was not observed with omega-hydroxycapsaicin; this arm of the study tested capsaicin rather than dihydrocapsaicin.\nCondition category: normal\nnutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin.\nplain_language: The parent compound jams the liver’s drug-clearing machinery; its hydroxylated product does not.\norganism: Rat\ntissue_or_cell_type: Liver\nexperimental_model: Incubation with phenobarbital-induced rat liver postmitochondrial supernatant, with rabbit urine confirmation and in vivo activity testing\nlimitations: Identifies side-chain hydroxylation as a shared detoxification route and shows the products are inactive. The enzyme-inhibition arm tested capsaicin, not dihydrocapsaicin, which is recorded on that claim.\nexposure: Capsaicin, dihydrocapsaicin and nonivamide incubated with an NADPH-generating system, with pentobarbital sleeping time as a readout of enzyme inhibition\nevidence_span: {\"source_cache\": \"artifacts/dihydrocapsaicin-research/8614248.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7c4eee5bf34dac159665170e5eca63fcbf3a5146133b9d7dc0b6ec01bda4493a\", \"start_char\": 0, \"end_char\": 1399, \"text_sha256\": \"7c4eee5bf34dac159665170e5eca63fcbf3a5146133b9d7dc0b6ec01bda4493a\"}\n[dhc-p8614248] Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications. 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