{"id":"c1d87b68-7f49-51ad-b77e-2b86f1e4a8ef","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-microbiome-trial","predicate":"alters_in_trial","statement":"The 120-person six-arm sweetener trial reported distinct microbiome and metabolome changes across the sweetener groups, including aspartame, over two weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6c517961-5cf0-5d95-b666-5a4882908434","mechanism_event_label":"A biological change need not equal a harmful clinical outcome.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"c2101aac-f43f-5d07-a319-80e4e84d60a6","slug":"human-aspartame-microbiome-response","display_name":"Human microbiome/metabolome response to aspartame","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6c517961-5cf0-5d95-b666-5a4882908434","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-microbiome-trial-event","event_type":"observed_relationship","label":"A biological change need not equal a harmful clinical outcome.","description":"The 120-person six-arm sweetener trial reported distinct microbiome and metabolome changes across the sweetener groups, including aspartame, over two weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c2101aac-f43f-5d07-a319-80e4e84d60a6","slug":"human-aspartame-microbiome-response","display_name":"Human microbiome/metabolome response to aspartame","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized human trial; aspartame arm compared with glucose-vehicle and no-supplement controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Total sample is not the aspartame-arm sample; no specific causal aspartame microbial metabolite is identified here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A biological change need not equal a harmful clinical outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35987213/ · DOI 10.1016/j.cell.2022.07.016","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f516276e-bbca-5c31-90c0-72fa4e79d744","evidence_kind":"source_excerpt","locator":"Lines 290-296","start_line":290,"end_line":296,"excerpt":"## aspartame-microbiome-trial\nA biological change need not equal a harmful clinical outcome.\nThe 120-person six-arm sweetener trial reported distinct microbiome and metabolome changes across the sweetener groups, including aspartame, over two weeks.\nModel: Randomized human trial; aspartame arm compared with glucose-vehicle and no-supplement controls.\nLimitations: Total sample is not the aspartame-arm sample; no specific causal aspartame microbial metabolite is identified here.\nEvidence access: Primary abstract\nPersonalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35987213/ · DOI 10.1016/j.cell.2022.07.016","model_system":"Randomized human trial; aspartame arm compared with glucose-vehicle and no-supplement controls.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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