{"id":"c1cf8e4e-30ad-5a15-a2ba-1107ac0b2964","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-optical-index","predicate":"modifies","statement":"Dissolved tartrazine reduced optical scattering by bringing the aqueous refractive index closer to that of high-index components.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"59943d22-5f05-5a1e-92c9-6c377df631d3","mechanism_event_label":"Dissolved tartrazine reduced optical scattering by bringing the aqueous refractive index closer to that of high-index components.","subject":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"object":{"id":"6915767d-ae2e-5486-b81f-d9ce91a02cd0","slug":"tartrazine-aqueous-refractive-index","display_name":"Refractive-index matching by aqueous tartrazine in optical phantoms","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"59943d22-5f05-5a1e-92c9-6c377df631d3","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-optical-index-event","event_type":"observed_relationship","label":"Dissolved tartrazine reduced optical scattering by bringing the aqueous refractive index closer to that of high-index components.","description":"Dissolved tartrazine reduced optical scattering by bringing the aqueous refractive index closer to that of high-index components.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6915767d-ae2e-5486-b81f-d9ce91a02cd0","slug":"tartrazine-aqueous-refractive-index","display_name":"Refractive-index matching by aqueous tartrazine in optical phantoms","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Tartrazine solution 0.6 M in representative optical phantom experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Optical measurements; no oral exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific experimental curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Aqueous silica scattering phantoms and ex vivo tissue experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Strong absorption alters refractive index and reduces scattering in a red spectral window; this is a physical mechanism, not receptor pharmacology or a dietary health effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Aqueous silica scattering phantoms and ex vivo tissue experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Dissolved tartrazine reduced optical scattering by bringing the aqueous refractive index closer to that of high-index components.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Achieving optical transparency in live animals with absorbing molecules. (2024). https://pubmed.ncbi.nlm.nih.gov/39236186/ DOI: 10.1126/science.adm6869","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Physical addition of dye to aqueous scattering medium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Optical refractive-index matching","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"34dd414a-498d-5e74-bd43-49c195630929","evidence_kind":"source_excerpt","locator":"Lines 435-444","start_line":435,"end_line":444,"excerpt":"## tartrazine-optical-index\nDissolved tartrazine reduced optical scattering by bringing the aqueous refractive index closer to that of high-index components.\nModel/species: Aqueous silica scattering phantoms and ex vivo tissue experiments\nTissue: Optical refractive-index matching\nExposure: Tartrazine solution 0.6 M in representative optical phantom experiment\nRoute: Physical addition of dye to aqueous scattering medium\nDuration: Optical measurements; no oral exposure\nLimits: Strong absorption alters refractive index and reduces scattering in a red spectral window; this is a physical mechanism, not receptor pharmacology or a dietary health effect.\nPrimary reference: Achieving optical transparency in live animals with absorbing molecules. (2024). https://pubmed.ncbi.nlm.nih.gov/39236186/ DOI: 10.1126/science.adm6869\nAccess: Primary full-text methods/results and metadata.","model_system":"Aqueous silica scattering phantoms and ex vivo tissue experiments","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; primary citation retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d9540941-68b4-5a0d-a5c1-828665a918e2","stable_key":"import-792249b7-a38d-5f43-afb6-2936818a3fa2","title":"Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. 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