{"id":"c16ec09d-d2d6-5f3f-a975-d5296e15a278","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-zinc-control-null","predicate":"no_significant_change","statement":"The small matched control subgroup showed no significant zinc change after tartrazine.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"55f97ef3-e8fc-5899-8485-6b9e0b3d8f98","mechanism_event_label":"The small matched control subgroup showed no significant zinc change after tartrazine.","subject":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"object":{"id":"a07d63ed-d727-53e6-b5a8-d7da4e403f73","slug":"human-control-child-zinc-response","display_name":"Serum and urinary zinc response in control children","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"55f97ef3-e8fc-5899-8485-6b9e0b3d8f98","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-zinc-control-null-event","event_type":"observed_relationship","label":"The small matched control subgroup showed no significant zinc change after tartrazine.","description":"The small matched control subgroup showed no significant zinc change after tartrazine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a07d63ed-d727-53e6-b5a8-d7da4e403f73","slug":"human-control-child-zinc-response","display_name":"Serum and urinary zinc response in control children","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Single 50 mg tartrazine beverage challenge","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"120 min monitoring","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific experimental curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Selected children with parent-reported food-color reactions; tartrazine group n=23, matched tartrazine control subgroup n=5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No placebo challenge group in this 1997 experiment; selected population and small control subgroup. The source reports significant changes, but provides no zinc balance or intracellular threshold. Association does not prove chelation, ADHD causation, or benefit from zinc supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Selected children with parent-reported food-color reactions; tartrazine group n=23, matched tartrazine control subgroup n=5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The small matched control subgroup showed no significant zinc change after tartrazine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Assessment of Chemical Factors in Relation to Child Hyperactivity (1997). https://doi.org/10.1080/13590849762466 DOI: 10.1080/13590849762466","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral beverage","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Serum and urine zinc","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c7f93c15-73a1-542e-a1ef-f8affc55c0b0","evidence_kind":"source_excerpt","locator":"Lines 303-312","start_line":303,"end_line":312,"excerpt":"## tartrazine-zinc-control-null\nThe small matched control subgroup showed no significant zinc change after tartrazine.\nModel/species: Selected children with parent-reported food-color reactions; tartrazine group n=23, matched tartrazine control subgroup n=5\nTissue: Serum and urine zinc\nExposure: Single 50 mg tartrazine beverage challenge\nRoute: Oral beverage\nDuration: 120 min monitoring\nLimits: No placebo challenge group in this 1997 experiment; selected population and small control subgroup. The source reports significant changes, but provides no zinc balance or intracellular threshold. Association does not prove chelation, ADHD causation, or benefit from zinc supplementation.\nPrimary reference: Assessment of Chemical Factors in Relation to Child Hyperactivity (1997). https://doi.org/10.1080/13590849762466 DOI: 10.1080/13590849762466\nAccess: Primary full-text methods/results and metadata.","model_system":"Selected children with parent-reported food-color reactions; tartrazine group n=23, matched tartrazine control subgroup n=5","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; primary citation retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d9540941-68b4-5a0d-a5c1-828665a918e2","stable_key":"import-792249b7-a38d-5f43-afb6-2936818a3fa2","title":"Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"b83a0113a4b743adc91c24504e488f47e10665386b299c4cb0543da8948f4246","revision_id":"3769070e-6af4-5b02-9d8e-f23c84edba1b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}