{"id":"c15cec90-4a74-5757-a30b-11dd693cf24a","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-enzyme-deficient-liver-carnitine","predicate":"deficiency-associated-with-lower","statement":"Hepatic carnitine was 148 +/- 9.8 nmol/g in vitamin-C-deficient guinea pigs versus 249 +/- 16.1 in controls; pair-fed animals measured 181 +/- 14.1 nmol/g (means +/- SEM).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6f72f3a6-e631-54fa-8326-d185478e82c8","mechanism_event_label":"Both vitamin C shortage and reduced food intake affected liver carnitine in this experiment.","subject":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"object":{"id":"e92d861f-086f-5f4a-9596-aa79a2162833","slug":"guinea-pig-liver-carnitine-concentration","display_name":"Guinea-pig liver carnitine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6f72f3a6-e631-54fa-8326-d185478e82c8","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:vc-enzyme-deficient-liver-carnitine-event","event_type":"observed_intervention","label":"Both vitamin C shortage and reduced food intake affected liver carnitine in this experiment.","description":"Hepatic carnitine was 148 +/- 9.8 nmol/g in vitamin-C-deficient guinea pigs versus 249 +/- 16.1 in controls; pair-fed animals measured 181 +/- 14.1 nmol/g (means +/- SEM).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"role":"dietary-factor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"measured-metabolite","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e92d861f-086f-5f4a-9596-aa79a2162833","slug":"guinea-pig-liver-carnitine-concentration","display_name":"Guinea-pig liver carnitine concentration","entity_type_key":"cellular_process"},"role":"readout","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Vitamin C chemistry in collagen, modified-lysine/carnitine metabolism or copper-dependent peptide/catecholamine processing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Guinea-pig vitamin C deficiency and pair-fed comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Vitamin C deficient, control and underfed pair-fed groups; duration not verified in abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not infer that every between-group comparison was statistically significant from these means; biosynthesis was not directly measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cavia porcellus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Both vitamin C shortage and reduced food intake affected liver carnitine in this experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[carnitine1983] Combined effect of ascorbic acid deficiency and underfeeding on the hepatic carnitine level in guinea-pigs. (1983). https://pubmed.ncbi.nlm.nih.gov/6852178/ DOI: 10.1007/bf01965181","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"eb832223-ab31-5505-95db-4f68ac36eec6","evidence_kind":"source_excerpt","locator":"Lines 741-752","start_line":741,"end_line":752,"excerpt":"### vc-enzyme-deficient-liver-carnitine\nHepatic carnitine was 148 +/- 9.8 nmol/g in vitamin-C-deficient guinea pigs versus 249 +/- 16.1 in controls; pair-fed animals measured 181 +/- 14.1 nmol/g (means +/- SEM).\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Both vitamin C shortage and reduced food intake affected liver carnitine in this experiment.\norganism: Cavia porcellus\ntissue_or_cell_type: Liver\nexperimental_model: Guinea-pig vitamin C deficiency and pair-fed comparison\nlimitations: Do not infer that every between-group comparison was statistically significant from these means; biosynthesis was not directly measured.\ncross_nutrient: Vitamin C chemistry in collagen, modified-lysine/carnitine metabolism or copper-dependent peptide/catecholamine processing.\nexposure: Vitamin C deficient, control and underfed pair-fed groups; duration not verified in abstract.\n[carnitine1983] Combined effect of ascorbic acid deficiency and underfeeding on the hepatic carnitine level in guinea-pigs. 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