{"id":"c1534ea7-2307-5b58-ba6a-3d73d7a2f149","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-met-tb","predicate":"metabolized_to","statement":"Caffeine N1-demethylation produced the specified dimethylxanthine; fluvoxamine reduced its formation clearance.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3e43ce9d-ba81-5b39-acc6-910885714d10","mechanism_event_label":"Caffeine produces a distinct metabolite that needs its own record.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"830701e1-923d-5a62-8b93-fcac17611e8d","slug":"theobromine","display_name":"Theobromine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"3e43ce9d-ba81-5b39-acc6-910885714d10","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-met-tb-event","event_type":"observed_relationship","label":"Caffeine produces a distinct metabolite that needs its own record.","description":"Caffeine N1-demethylation produced the specified dimethylxanthine; fluvoxamine reduced its formation clearance.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"830701e1-923d-5a62-8b93-fcac17611e8d","slug":"theobromine","display_name":"Theobromine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9b15c13c-a369-5d10-a76a-525e8b19221d","slug":"cyp1a2","display_name":"Human cytochrome P450 1A2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"CYP1A2 is the principal demethylating route; minor routes and individual clearance vary.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Caffeine produces a distinct metabolite that needs its own record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A fluvoxamine-caffeine interaction study. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8807660/ · DOI 10.1097/00008571-199606000-00003","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9ba7c419-6648-5738-bc69-a194cb5b9a8a","evidence_kind":"source_excerpt","locator":"Lines 180-186","start_line":180,"end_line":186,"excerpt":"## caf-met-tb\nCaffeine produces a distinct metabolite that needs its own record.\nCaffeine N1-demethylation produced the specified dimethylxanthine; fluvoxamine reduced its formation clearance.\nModel: Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers.\nLimitations: CYP1A2 is the principal demethylating route; minor routes and individual clearance vary.\nEvidence access: Primary abstract\nA fluvoxamine-caffeine interaction study. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8807660/ · DOI 10.1097/00008571-199606000-00003","model_system":"Human caffeine/fluvoxamine crossover and metabolite measurements; eight healthy volunteers.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}