{"id":"c0c497c2-ebaa-5d8f-9398-505832673e80","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-ugt1a1","predicate":"forms","statement":"Human UGT1A1 predominantly formed the 3-O glucuronide of trans-resveratrol in microsomal/recombinant experiments; reported Km was 149 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"48100d4d-b201-55b3-9846-aa5e137b13ca","mechanism_event_label":"An independently named enzyme produces an independently named metabolite.","subject":{"id":"a54855e7-1ba5-5d14-8c14-70f06248ae5a","slug":"ugt1a1","display_name":"Human UDP-glucuronosyltransferase 1A1 / UGT1A1","entity_type_key":"protein"},"object":{"id":"8f6d2f8f-6fc3-594d-aa51-f8e6b55be195","slug":"resveratrol-3-o-glucuronide","display_name":"Resveratrol 3-O-glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"48100d4d-b201-55b3-9846-aa5e137b13ca","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-ugt1a1-event","event_type":"observed_relationship","label":"An independently named enzyme produces an independently named metabolite.","description":"Human UGT1A1 predominantly formed the 3-O glucuronide of trans-resveratrol in microsomal/recombinant experiments; 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Km is not a human plasma target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An independently named enzyme produces an independently named metabolite.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16597364/ · DOI 10.1211/jpp.58.4.0006","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"65281917-ca34-5f9f-b4b8-18d8eec5ff21","evidence_kind":"source_excerpt","locator":"Lines 30-36","start_line":30,"end_line":36,"excerpt":"## resveratrol-ugt1a1\nAn independently named enzyme produces an independently named metabolite.\nHuman UGT1A1 predominantly formed the 3-O glucuronide of trans-resveratrol in microsomal/recombinant experiments; reported Km was 149 micromolar.\nModel: Human liver/intestine microsomes and recombinant UGTs.\nLimitations: Predominant contribution is not exclusive specificity; Km is not a human plasma target.\nEvidence access: Primary abstract\nGlucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16597364/ · DOI 10.1211/jpp.58.4.0006","model_system":"Human liver/intestine microsomes and recombinant UGTs.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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