{"id":"c099bee8-2714-56d8-be00-44f808d6a4a8","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-human-oxidation-response","predicate":"increases","statement":"High threonine intake supplied either as free amino acid or protein increased measured threonine oxidation to CO2 approximately threefold.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f9ff867b-24e1-5855-adbc-056898e15fce","mechanism_event_label":"Extra intake can increase disposal rather than being retained unchanged.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"3924092c-442d-5fa2-8f0e-9f6e2ae6d98a","slug":"human-threonine-carbon-dioxide-oxidation","display_name":"Human threonine oxidation to carbon dioxide","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f9ff867b-24e1-5855-adbc-056898e15fce","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-human-oxidation-response-event","event_type":"observed_relationship","label":"Extra intake can increase disposal rather than being retained unchanged.","description":"High threonine intake supplied either as free amino acid or protein increased measured threonine oxidation to CO2 approximately threefold.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3924092c-442d-5fa2-8f0e-9f6e2ae6d98a","slug":"human-threonine-carbon-dioxide-oxidation","display_name":"Human threonine oxidation to carbon dioxide","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same six men; control intake 50 versus 126 micromol/kg/hour in the two high-intake conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short controlled feeding/tracer study; not a long-term benefit or safety threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Extra intake can increase disposal rather than being retained unchanged.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10780944/ · DOI 10.1152/ajpendo.2000.278.5.E877","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cf198a4e-09fe-55c1-8593-f774cf12b078","evidence_kind":"source_excerpt","locator":"Lines 298-304","start_line":298,"end_line":304,"excerpt":"## l-threonine-human-oxidation-response\nExtra intake can increase disposal rather than being retained unchanged.\nHigh threonine intake supplied either as free amino acid or protein increased measured threonine oxidation to CO2 approximately threefold.\nModel: Same six men; control intake 50 versus 126 micromol/kg/hour in the two high-intake conditions.\nLimitations: Short controlled feeding/tracer study; not a long-term benefit or safety threshold.\nEvidence access: Primary abstract\nThreonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10780944/ · DOI 10.1152/ajpendo.2000.278.5.E877","model_system":"Same six men; control intake 50 versus 126 micromol/kg/hour in the two high-intake conditions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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