{"id":"c063910b-62ef-52fe-ad11-0c481fdd3f2a","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-intestinal-location","predicate":"localizes_to","statement":"NIS immunolocalization in rat small-intestinal enterocytes was restricted to their apical surface.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"e36494fc-3705-5e10-9d03-8d27c67696ba","mechanism_event_label":"In the intestine, NIS faces the dietary contents.","subject":{"id":"acfbc5ec-b299-5365-8c5d-9e492c18d1d9","slug":"rat-slc5a5","display_name":"Rat sodium/iodide symporter / Slc5a5","entity_type_key":"protein"},"object":{"id":"70ddec47-5cc3-5b1c-9d17-c0c7f1609d49","slug":"intestinal-epithelial-apical-membrane","display_name":"Intestinal epithelial apical membrane","entity_type_key":"organelle"},"evidence_count":1,"mechanism_event":{"id":"e36494fc-3705-5e10-9d03-8d27c67696ba","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-intestinal-location-event","event_type":"observed_intervention","label":"In the intestine, NIS faces the dietary contents.","description":"NIS immunolocalization in rat small-intestinal enterocytes was restricted to their apical surface.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"acfbc5ec-b299-5365-8c5d-9e492c18d1d9","slug":"rat-slc5a5","display_name":"Rat sodium/iodide symporter / Slc5a5","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"70ddec47-5cc3-5b1c-9d17-c0c7f1609d49","slug":"intestinal-epithelial-apical-membrane","display_name":"Intestinal epithelial apical membrane","entity_type_key":"organelle"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat and mouse intestinal localization, intestinal brush-border vesicles and IEC-6 cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tissue localization; no intake intervention used for this claim.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Anatomical localization does not quantify the fraction of human iodine absorbed through this route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In the intestine, NIS faces the dietary contents.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-trans-intestine2009] The Na+/I- symporter mediates active iodide uptake in the intestine. (2009). https://pubmed.ncbi.nlm.nih.gov/19052257/ DOI: 10.1152/ajpcell.00509.2008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Small-intestinal enterocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aa9671f4-a21d-5370-92b2-6035060ef8a9","evidence_kind":"source_excerpt","locator":"Lines 245-256","start_line":245,"end_line":256,"excerpt":"### iodine-trans-intestinal-location\nNIS immunolocalization in rat small-intestinal enterocytes was restricted to their apical surface.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In the intestine, NIS faces the dietary contents.\norganism: Rattus norvegicus\ntissue_or_cell_type: Small-intestinal enterocytes\nexperimental_model: Rat and mouse intestinal localization, intestinal brush-border vesicles and IEC-6 cells\nlimitations: Anatomical localization does not quantify the fraction of human iodine absorbed through this route.\nexposure: Tissue localization; no intake intervention used for this claim.\ncross_nutrient: false\n[iodine-trans-intestine2009] The Na+/I- symporter mediates active iodide uptake in the intestine. (2009). https://pubmed.ncbi.nlm.nih.gov/19052257/ DOI: 10.1152/ajpcell.00509.2008","model_system":"Rat and mouse intestinal localization, intestinal brush-border vesicles and IEC-6 cells","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iodine-trans-intestine2009] The Na+/I- symporter mediates active iodide uptake in the intestine. (2009). https://pubmed.ncbi.nlm.nih.gov/19052257/ DOI: 10.1152/ajpcell.00509.2008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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