{"id":"c023c6ae-d7d4-59db-8dcc-6495d177e446","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-cadmium-urine","predicate":"associated_with_increased","statement":"Urinary cadmium was 150% higher on day six, with reported p<0.05.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b3e34257-7012-575b-9f88-42e3449fcb93","mechanism_event_label":"The pilot also reported more cadmium excretion.","subject":{"id":"cd34197d-e78f-5adb-80a9-eb423fb115c4","slug":"modified-citrus-pectin","display_name":"Modified citrus pectin, product-specific","entity_type_key":"chemical_species"},"object":{"id":"ec1440c7-4a51-5512-b157-94693177e707","slug":"urinary-cadmium-excretion","display_name":"Human urinary cadmium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b3e34257-7012-575b-9f88-42e3449fcb93","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-cadmium-urine-event","event_type":"observed_intervention","label":"The pilot also reported more cadmium excretion.","description":"Urinary cadmium was 150% higher on day six, with reported p<0.05.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cd34197d-e78f-5adb-80a9-eb423fb115c4","slug":"modified-citrus-pectin","display_name":"Modified citrus pectin, product-specific","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ec1440c7-4a51-5512-b157-94693177e707","slug":"urinary-cadmium-excretion","display_name":"Human urinary cadmium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/16835878.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ba618bbf53b858a6295bf517eb175d297b6632e62e6f067acb97f7e032e1d935\", \"start_char\": 0, \"end_char\": 1337, \"text_sha256\": \"ba618bbf53b858a6295bf517eb175d297b6632e62e6f067acb97f7e032e1d935\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Uncontrolled exploratory urinary element excretion study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"PectaSol MCP: mean molecular weight 15400, DE3.8%; 15 g/day five days and 20 g on day six","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No randomized comparator, whole-body burden endpoint or demonstrated systemic chelation mechanism. Urinary excretion is not proof of clinical detoxification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The pilot also reported more cadmium excretion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p16835878] The effect of modified citrus pectin on urinary excretion of toxic elements. (2006). https://pubmed.ncbi.nlm.nih.gov/16835878/ DOI: 10.1002/ptr.1953","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"24-hour urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e364ddef-9169-5ea4-a182-dedd5a06cd0f","evidence_kind":"source_excerpt","locator":"Lines 1101-1112","start_line":1101,"end_line":1112,"excerpt":"### pectin-cadmium-urine\nUrinary cadmium was 150% higher on day six, with reported p<0.05.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The pilot also reported more cadmium excretion.\norganism: Homo sapiens\ntissue_or_cell_type: 24-hour urine\nexperimental_model: Uncontrolled exploratory urinary element excretion study\nlimitations: No randomized comparator, whole-body burden endpoint or demonstrated systemic chelation mechanism. Urinary excretion is not proof of clinical detoxification.\nexposure: PectaSol MCP: mean molecular weight 15400, DE3.8%; 15 g/day five days and 20 g on day six\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/16835878.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ba618bbf53b858a6295bf517eb175d297b6632e62e6f067acb97f7e032e1d935\", \"start_char\": 0, \"end_char\": 1337, \"text_sha256\": \"ba618bbf53b858a6295bf517eb175d297b6632e62e6f067acb97f7e032e1d935\"}\n[pectin-p16835878] The effect of modified citrus pectin on urinary excretion of toxic elements. (2006). https://pubmed.ncbi.nlm.nih.gov/16835878/ DOI: 10.1002/ptr.1953","model_system":"Uncontrolled exploratory urinary element excretion study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [pectin-p16835878] The effect of modified citrus pectin on urinary excretion of toxic elements. (2006). https://pubmed.ncbi.nlm.nih.gov/16835878/ DOI: 10.1002/ptr.1953","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"13c3aae7-702f-5bc9-9fca-a57d141882ce","stable_key":"import-d17caac5-7018-5ca8-9e96-95afeb384bc4","title":"Pectin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff07001bc37d008a1e23fbba37146d0b0d33cc8c0bf42a75f1e1a7ef0aaeb489","revision_id":"76f1a2c5-02d0-511b-bde5-33079d7af6a0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}