{"id":"bfe3cdd8-dec2-508b-9658-62f3e41e6703","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:eight-weeks-of-supplementation-prolongs-prothrombin-time-within-group","predicate":"increases","statement":"Prothrombin time rose significantly within the nattokinase group over eight weeks, but the between-group comparison against placebo was significant only for closure time and aPTT.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d88d879b-1179-55af-ae64-84fabb7f4c55","mechanism_event_label":"Prothrombin time rose significantly within the nattokinase group over eight weeks, but the between-group comparison against placebo was significant only for closure time and aPTT.","subject":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"b7158a85-ee6b-5df1-9e3f-7a01c29d5f2d","slug":"prothrombin-time","display_name":"Prothrombin time","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d88d879b-1179-55af-ae64-84fabb7f4c55","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:eight-weeks-of-supplementation-prolongs-prothrombin-time-within-group-event","event_type":"observed_intervention","label":"Prothrombin time rose significantly within the nattokinase group over eight weeks, but the between-group comparison against placebo was significant only for closure time and aPTT.","description":"Plasma","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b7158a85-ee6b-5df1-9e3f-7a01c29d5f2d","slug":"prothrombin-time","display_name":"Prothrombin time","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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