{"id":"bfb4bbbf-96fd-51ca-93e0-b244316c627e","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-d-glut1-docking","predicate":"has_proposed_binding_to","statement":"Molecular docking proposed cucurbitacin D binding to GLUT1.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d9373348-5529-5032-a873-1ce602e7bd7b","mechanism_event_label":"Direct transporter binding remains a prediction in this evidence record.","subject":{"id":"13edf322-5d31-5a4e-802f-c7528fc2ef48","slug":"cucurbitacin-d","display_name":"Cucurbitacin D","entity_type_key":"small_molecule"},"object":{"id":"ffb5e632-9a8e-5bed-97eb-56a9ecdd856f","slug":"slc2a1","display_name":"Human glucose transporter 1 / SLC2A1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"d9373348-5529-5032-a873-1ce602e7bd7b","stable_key":"2921131d-0ba0-51d3-8f59-8c4be3b9ac08:cucurbitacin-d-glut1-docking-event","event_type":"observed_relationship","label":"Direct transporter binding remains a prediction in this evidence record.","description":"Molecular docking proposed cucurbitacin D binding to GLUT1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13edf322-5d31-5a4e-802f-c7528fc2ef48","slug":"cucurbitacin-d","display_name":"Cucurbitacin D","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ffb5e632-9a8e-5bed-97eb-56a9ecdd856f","slug":"slc2a1","display_name":"Human glucose transporter 1 / SLC2A1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Computational docking within the glucose-metabolism study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No transporter-binding kinetics or reconstituted transport-inhibition measurement was established by docking.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cucurbitacins collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cucurbitacin","display_name":"Cucurbitacins","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Direct transporter binding remains a prediction in this evidence record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30875788/ · DOI 10.3390/cancers11030364","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"579e3465-c1eb-5ff2-8733-830cc810a68a","evidence_kind":"source_excerpt","locator":"Lines 324-330","start_line":324,"end_line":330,"excerpt":"## cucurbitacin-d-glut1-docking\nDirect transporter binding remains a prediction in this evidence record.\nMolecular docking proposed cucurbitacin D binding to GLUT1.\nModel: Computational docking within the glucose-metabolism study.\nLimitations: No transporter-binding kinetics or reconstituted transport-inhibition measurement was established by docking.\nEvidence access: Primary abstract\nCucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30875788/ · DOI 10.3390/cancers11030364","model_system":"Computational docking within the glucose-metabolism study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"77324310-00ce-5d28-9fc7-595fddae86b9","stable_key":"import-2921131d-0ba0-51d3-8f59-8c4be3b9ac08","title":"Cucurbitacins: thiol chemistry, cytoskeleton, metabolic dependencies and signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"5c23ec61b9cf3d2966fb081d8617e1e1f7c522e86419b8ba2dcae09590121123","revision_id":"74251a06-3ba5-506c-b428-700eca0fb432","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}