{"id":"bfac0964-9498-56c0-b4b0-3612b135ed09","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:bone-calcium-in-solid-apatite","predicate":"mineral_component_of","statement":"Mature zebrafish fin-ray bone contains crystalline carbonated apatite platelets embedded in an organized collagen matrix.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"31672479-7fed-5bd4-8f2c-e8c479692ec7","mechanism_event_label":"Bone contains calcium in a solid mineral phase, distinct from dissolved calcium ions.","subject":{"id":"d515a301-29a6-5d2d-88db-44773711406a","slug":"hydroxyapatite","display_name":"Hydroxyapatite / biological substituted apatite","entity_type_key":"chemical_species"},"object":{"id":"7dbb4c2f-3f94-5f0b-abfc-980d8a4105d5","slug":"bone-extracellular-matrix","display_name":"Bone extracellular matrix","entity_type_key":"tissue"},"evidence_count":1,"mechanism_event":{"id":"31672479-7fed-5bd4-8f2c-e8c479692ec7","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:bone-calcium-in-solid-apatite-event","event_type":"biochemical_relationship","label":"Bone contains calcium in a solid mineral phase, distinct from dissolved calcium ions.","description":"Mature zebrafish fin-ray bone contains crystalline carbonated apatite platelets embedded in an organized collagen matrix.","status":"provisional","compartment":{"slug":"bone-extracellular-matrix","display_name":"Bone extracellular matrix"},"participants":[{"entity":{"id":"d515a301-29a6-5d2d-88db-44773711406a","slug":"hydroxyapatite","display_name":"Hydroxyapatite / biological substituted apatite","entity_type_key":"chemical_species"},"role":"mineral_phase","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"lattice_constituent_not_free_solute","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; protonation depends on pH)","entity_type_key":"ion"},"role":"mineral_constituent","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7dbb4c2f-3f94-5f0b-abfc-980d8a4105d5","slug":"bone-extracellular-matrix","display_name":"Bone extracellular matrix","entity_type_key":"tissue"},"role":"mineralized_matrix","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7dbb4c2f-3f94-5f0b-abfc-980d8a4105d5","slug":"bone-extracellular-matrix","display_name":"Bone extracellular matrix","entity_type_key":"tissue"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":4,"notes":"Study location; presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"Bone extracellular matrix","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Microscopy, diffraction and elemental analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Biological apatite is substituted and nonstoichiometric; the ideal hydroxyapatite formula is not an exact tissue composition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Danio rerio","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Bone contains calcium in a solid mineral phase, distinct from dissolved calcium ions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mahamid2008] Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2529085/ DOI: 10.1073/pnas.0803354105","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fin-ray bone","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3f5097b3-cfb3-510d-b72f-3499def060b9","evidence_kind":"source_excerpt","locator":"Lines 862-872","start_line":862,"end_line":872,"excerpt":"### bone-calcium-in-solid-apatite\nMature zebrafish fin-ray bone contains crystalline carbonated apatite platelets embedded in an organized collagen matrix.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Bone contains calcium in a solid mineral phase, distinct from dissolved calcium ions.\norganism: Danio rerio\ntissue_or_cell_type: Fin-ray bone\nexperimental_model: Microscopy, diffraction and elemental analysis\nlimitations: Biological apatite is substituted and nonstoichiometric; the ideal hydroxyapatite formula is not an exact tissue composition.\ncompartment_description: Bone extracellular matrix\n[mahamid2008] Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2529085/ DOI: 10.1073/pnas.0803354105","model_system":"Microscopy, diffraction and elemental analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mahamid2008] Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase (2008). https://pmc.ncbi.nlm.nih.gov/articles/PMC2529085/ DOI: 10.1073/pnas.0803354105","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}