{"id":"bf8181cb-fa81-52d3-8d85-2c514c469f16","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-pept1","predicate":"transports","statement":"Applying carnosine to oocytes expressing human PEPT1 produced electrogenic proton-coupled transport currents.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9adfb210-8a8e-5706-b316-ed89cbb7a413","mechanism_event_label":"A peptide transporter can carry intact carnosine.","subject":{"id":"9b143910-883a-5c72-82b7-bc3ca33341e7","slug":"human-slc15a1","display_name":"Human proton-coupled peptide transporter 1 / SLC15A1","entity_type_key":"protein"},"object":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"9adfb210-8a8e-5706-b316-ed89cbb7a413","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-pept1-event","event_type":"observed_relationship","label":"A peptide transporter can carry intact carnosine.","description":"Applying carnosine to oocytes expressing human PEPT1 produced electrogenic proton-coupled transport currents.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9b143910-883a-5c72-82b7-bc3ca33341e7","slug":"human-slc15a1","display_name":"Human proton-coupled peptide transporter 1 / SLC15A1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"16a9848a-023b-5828-9fd1-e28b9eadb901","slug":"hydrogen-ion","display_name":"Hydrogen ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human transporter expressed in Xenopus oocytes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transporter expression system, not whole-body bioavailability.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A peptide transporter can carry intact carnosine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20067523/ · DOI 10.1111/j.1742-4658.2009.07528.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Applying carnosine produced electrogenic proton-coupled inward transport currents.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Applying carnosine produced electrogenic proton-coupled inward transport currents.","entity":null}],"evidence":[{"id":"9d1ad387-f195-5058-bb60-d2a0f3183fe1","evidence_kind":"source_excerpt","locator":"Lines 68-74","start_line":68,"end_line":74,"excerpt":"## carnosine-pept1\nA peptide transporter can carry intact carnosine.\nApplying carnosine to oocytes expressing human PEPT1 produced electrogenic proton-coupled transport currents.\nModel: Human transporter expressed in Xenopus oocytes.\nLimitations: Transporter expression system, not whole-body bioavailability.\nEvidence access: Primary abstract\nThe bioactive dipeptide anserine is transported by human proton-coupled peptide transporters. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20067523/ · DOI 10.1111/j.1742-4658.2009.07528.x","model_system":"Human transporter expressed in Xenopus oocytes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}