{"id":"bf739941-46d4-50a7-afc6-2afcbc00a96d","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:ngfr-expression","predicate":"increases_in_recorded_comparison","statement":"ALCAR increased p75NGFR mRNA, immunoprecipitable receptor and NGF binding in PC12 cells.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"f0c0748e-c5e6-5fc9-9493-a8d226e3c5c0","mechanism_event_label":"ALCAR increased p75NGFR mRNA, immunoprecipitable receptor and NGF binding in PC12 cells.","subject":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"object":{"id":"6c2545da-a0d5-5e28-9aa8-ef630a1cd13d","slug":"rat-pc12-p75-expression","display_name":"Rat PC12 p75 neurotrophin-receptor expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f0c0748e-c5e6-5fc9-9493-a8d226e3c5c0","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:ngfr-expression-event","event_type":"experimental_observation","label":"ALCAR increased p75NGFR mRNA, immunoprecipitable receptor and NGF binding in PC12 cells.","description":"### ngfr-expression\n\nALCAR increased p75NGFR mRNA, immunoprecipitable receptor and NGF binding in PC12 cells.\nThis concerns NGFR/p75, not an automatic claim about NTRK1/TrkA expression or direct NGF-receptor agonism.\nModel and exposure: Rat PC12 cell experiments, 1992; abstract access, dose/time not extracted.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. | 1992 | https://pubmed.ncbi.nlm.nih.gov/1324679/ | https://doi.org/10.1016/0006-2952(92)90452-o | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"ALCAR treatment","sequence_order":0,"notes":""},{"entity":{"id":"6c2545da-a0d5-5e28-9aa8-ef630a1cd13d","slug":"rat-pc12-p75-expression","display_name":"Rat PC12 p75 neurotrophin-receptor expression","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""},{"entity":{"id":"5d3bc8ab-f029-518c-b165-1a4176ebb81c","slug":"rat-ngfr","display_name":"Rat p75 neurotrophin receptor / Ngfr","entity_type_key":"protein"},"role":"measured receptor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"ALCAR treatment\", \"comparator\": \"Untreated PC12 control\", \"endpoint\": \"ALCAR increased p75NGFR mRNA, immunoprecipitable receptor and NGF binding in PC12 cells.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Rat PC12 cell experiments, 1992; abstract access, dose/time not extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived curation with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"ALCAR increased p75NGFR mRNA, immunoprecipitable receptor and NGF binding in PC12 cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. | https://pubmed.ncbi.nlm.nih.gov/1324679/ | https://doi.org/10.1016/0006-2952(92)90452-o","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ngfr-expression; This concerns NGFR/p75, not an automatic claim about NTRK1/TrkA expression or direct NGF-receptor agonism.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"330aa96a-3203-57e8-9f3f-e96304d0a9fb","evidence_kind":"source_excerpt","locator":"Lines 172-178","start_line":172,"end_line":178,"excerpt":"### ngfr-expression\n\nALCAR increased p75NGFR mRNA, immunoprecipitable receptor and NGF binding in PC12 cells.\nThis concerns NGFR/p75, not an automatic claim about NTRK1/TrkA expression or direct NGF-receptor agonism.\nModel and exposure: Rat PC12 cell experiments, 1992; abstract access, dose/time not extracted.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Stimulation of nerve growth factor receptors in PC12 by acetyl-L-carnitine. | 1992 | https://pubmed.ncbi.nlm.nih.gov/1324679/ | https://doi.org/10.1016/0006-2952(92)90452-o | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Rat PC12 cell experiments, 1992; abstract access, dose/time not extracted.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2588f904-245a-597a-8a12-65118013fb90","stable_key":"import-e3f6ce02-0bd7-5103-acc1-68503ab6751b","title":"Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed.","file_path":"","sha256":"84cc82d6fbb0fd5d73c4ce779e9f88e7f0184ba2d29b18ad0f153815380f2975","revision_id":"dac7a950-dbe5-5c7a-9c70-2ea711d5c71a","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}