{"id":"bf53af35-5562-5980-800c-293c206e4c68","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-hepatic-compensation","predicate":"liver_deletion_recruits","statement":"Liver-specific Cdo1 deletion increased extrahepatic CDO abundance and hypotaurine; mice maintained taurine, glutathione and sulfate despite a taurine-free diet.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6a4b0ae1-c478-5f04-b277-d824fc75bd6e","mechanism_event_label":"Other tissues compensated when liver synthesis was impaired.","subject":{"id":"5b392029-0f75-5ff2-b346-28bd11fff628","slug":"mouse-cdo1","display_name":"Mouse cysteine dioxygenase / Cdo1","entity_type_key":"protein"},"object":{"id":"bc1bc54e-20a6-566f-aef8-ba7a9c0a3372","slug":"mouse-extrahepatic-taurine-synthesis","display_name":"Extrahepatic compensation for hepatic Cdo1 loss in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6a4b0ae1-c478-5f04-b277-d824fc75bd6e","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-hepatic-compensation-event","event_type":"observed_relationship","label":"Other tissues compensated when liver synthesis was impaired.","description":"Liver-specific Cdo1 deletion increased extrahepatic CDO abundance and hypotaurine; mice maintained taurine, glutathione and sulfate despite a taurine-free diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5b392029-0f75-5ff2-b346-28bd11fff628","slug":"mouse-cdo1","display_name":"Mouse cysteine dioxygenase / Cdo1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bc1bc54e-20a6-566f-aef8-ba7a9c0a3372","slug":"mouse-extrahepatic-taurine-synthesis","display_name":"Extrahepatic compensation for hepatic Cdo1 loss in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"eeff5174-9aa8-5f34-b107-e826edde648c","slug":"hypotaurine","display_name":"Hypotaurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional mouse liver knockout; kidney, adipose and pancreatic measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This tissue-restricted deletion differs from complete pathway loss and from human deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Other tissues compensated when liver synthesis was impaired.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22414809/ · DOI 10.1152/ajpendo.00589.2011","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2a2eb809-328d-5622-b4ac-f6c506e8d75f","evidence_kind":"source_excerpt","locator":"Lines 97-103","start_line":97,"end_line":103,"excerpt":"## taurine-hepatic-compensation\nOther tissues compensated when liver synthesis was impaired.\nLiver-specific Cdo1 deletion increased extrahepatic CDO abundance and hypotaurine; mice maintained taurine, glutathione and sulfate despite a taurine-free diet.\nModel: Conditional mouse liver knockout; kidney, adipose and pancreatic measurements.\nLimitations: This tissue-restricted deletion differs from complete pathway loss and from human deficiency.\nEvidence access: Primary abstract\nExtrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22414809/ · DOI 10.1152/ajpendo.00589.2011","model_system":"Conditional mouse liver knockout; kidney, adipose and pancreatic measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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