{"id":"bf460ad3-98bf-5737-9457-e74955bdf06c","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-r-odor-threshold","predicate":"has_detection_threshold","statement":"The reported sensory detection threshold for R-gamma-nonalactone was 66 micrograms/L.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"1cc45de3-fdba-540d-b249-016a9a4da977","mechanism_event_label":"The reported sensory detection threshold for R-gamma-nonalactone was 66 micrograms/L.","subject":{"id":"82042b3d-808a-5d87-b52b-c76694a2f139","slug":"r-gamma-nonalactone","display_name":"(R)-Gamma-nonalactone","entity_type_key":"small_molecule"},"object":{"id":"b303bee8-2600-5cbf-8a5f-2d03cbcf8539","slug":"human-gamma-nonalactone-odor-detection","display_name":"Human gamma-nonalactone aroma detection","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1cc45de3-fdba-540d-b249-016a9a4da977","stable_key":"8600a864-6653-52c7-9718-1362c5af4577:gamma-nonalactone-r-odor-threshold-event","event_type":"observed_relationship","label":"The reported sensory detection threshold for R-gamma-nonalactone was 66 micrograms/L.","description":"The reported sensory detection threshold for R-gamma-nonalactone was 66 micrograms/L.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82042b3d-808a-5d87-b52b-c76694a2f139","slug":"r-gamma-nonalactone","display_name":"(R)-Gamma-nonalactone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b303bee8-2600-5cbf-8a5f-2d03cbcf8539","slug":"human-gamma-nonalactone-odor-detection","display_name":"Human gamma-nonalactone aroma detection","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b85fa4a-5c91-5de9-aead-a443bc4394af","slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"R and S gamma-nonalactone concentration series","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Threshold-testing interval not specified in abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; unresolved method details explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human sensory detection tests reported with grape/wine enantiomer study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Enantiomer thresholds depend on matrix and protocol. No olfactory receptor identity or general threshold across foods is established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gamma-nonalactone flavor-compound chapter; nutrient and drug interactions retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gamma-nonalactone","display_name":"Gamma-nonalactone","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human sensory detection tests reported with grape/wine enantiomer study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The reported sensory detection threshold for R-gamma-nonalactone was 66 micrograms/L.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aromatic Potential of Bordeaux Grape Cultivars: Identification and Assays on 4-Oxononanoic Acid, a γ-Nonalactone Precursor. (2020). https://pubmed.ncbi.nlm.nih.gov/32955257/ DOI: 10.1021/acs.jafc.0c04171","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Sensory exposure; exact test matrix and panel size unresolved in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Olfactory perception","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"12b6d49a-507f-5b87-bc04-1d744f609139","evidence_kind":"source_excerpt","locator":"Lines 180-189","start_line":180,"end_line":189,"excerpt":"## gamma-nonalactone-r-odor-threshold\nThe reported sensory detection threshold for R-gamma-nonalactone was 66 micrograms/L.\nModel/species: Human sensory detection tests reported with grape/wine enantiomer study\nTissue: Olfactory perception\nExposure: R and S gamma-nonalactone concentration series\nRoute: Sensory exposure; exact test matrix and panel size unresolved in accessed abstract\nDuration: Threshold-testing interval not specified in abstract\nLimits: Enantiomer thresholds depend on matrix and protocol. No olfactory receptor identity or general threshold across foods is established.\nPrimary reference: Aromatic Potential of Bordeaux Grape Cultivars: Identification and Assays on 4-Oxononanoic Acid, a γ-Nonalactone Precursor. (2020). https://pubmed.ncbi.nlm.nih.gov/32955257/ DOI: 10.1021/acs.jafc.0c04171\nAccess: Primary PubMed abstract; unresolved method details explicitly retained.","model_system":"Human sensory detection tests reported with grape/wine enantiomer study","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73777c54-95a4-5b07-9d14-d4dd31949fb1","stable_key":"import-8600a864-6653-52c7-9718-1362c5af4577","title":"Gamma-nonalactone: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eight primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"a6fede6fbb2b70669be6846626f9c197edfd605c627d50fffa984e2b0b7ed71d","revision_id":"bb5ac9d2-d97d-59ac-a99c-ddf46d535574","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}