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[Niello et al., 2026](https://doi.org/10.1016/j.neuropharm.2026.110969)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9a93dc49-b3f6-5cf9-b6e5-7318c2f43ac2","slug":"s-mk-26","display_name":"S-MK-26 modafinil analogue","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"Tested analogue","sequence_order":0,"notes":""},{"entity":{"id":"3c5ea51a-585a-596a-9398-69a1a7b05722","slug":"rat-analogue-cognitive-response","display_name":"Rat cognitive responses to modafinil analogues","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"mixed","sequence_order":1,"notes":""},{"entity":{"id":"a61c79bf-b0f9-5c6e-a465-2e210f77a5ac","slug":"armodafinil","display_name":"Armodafinil / R-modafinil","entity_type_key":"drug"},"role":"comparative compound","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract and publisher experimental procedures, results and discussion inspected; no supplementary-data reanalysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Tested analogue\", \"comparator\": \"Study comparator\", \"endpoint\": \"More slowly dissociating analogues including s-mk-26 performed better on selected rat cognitive outcomes, including scopolamine-impaired tasks; brain exposure also differed.\", \"effect_direction\": \"mixed\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Rat cognition, analogue exposure and dopamine experiments; residence-time causality not isolated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. 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