{"id":"bf102267-ff6e-54bc-909b-9b8b7bc76f04","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-iron-liposome","predicate":"inhibits","statement":"Astaxanthin inhibited ADP/Fe2+-initiated liposome peroxidation more strongly than beta-carotene in this assay; chemical degradation patterns suggested contributions from both its polyene and terminal rings.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6d39739c-8976-575b-8382-40d1517eb747","mechanism_event_label":"Different regions of the molecule may participate in radical trapping.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6d39739c-8976-575b-8382-40d1517eb747","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-iron-liposome-event","event_type":"observed_relationship","label":"Different regions of the molecule may participate in radical trapping.","description":"Astaxanthin inhibited ADP/Fe2+-initiated liposome peroxidation more strongly than beta-carotene in this assay; chemical degradation patterns suggested contributions from both its polyene and terminal rings.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free phospholipid liposomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Regional chemistry was inferred from oxidation products, not direct proof of a permanently membrane-spanning orientation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Different regions of the molecule may participate in radical trapping.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11406102/ · DOI 10.1016/s0005-2736(01)00326-1","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"305cc3dc-1269-5a8c-baba-3566dfcaea72","evidence_kind":"source_excerpt","locator":"Lines 158-164","start_line":158,"end_line":164,"excerpt":"## astaxanthin-iron-liposome\nDifferent regions of the molecule may participate in radical trapping.\nAstaxanthin inhibited ADP/Fe2+-initiated liposome peroxidation more strongly than beta-carotene in this assay; chemical degradation patterns suggested contributions from both its polyene and terminal rings.\nModel: Cell-free phospholipid liposomes.\nLimitations: Regional chemistry was inferred from oxidation products, not direct proof of a permanently membrane-spanning orientation.\nEvidence access: Primary abstract\nEfficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11406102/ · DOI 10.1016/s0005-2736(01)00326-1","model_system":"Cell-free phospholipid liposomes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}