{"id":"bed12dc7-9357-5675-8c45-5c3547c322b8","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-hlcs-forms","predicate":"inhibits_more_potently_than","statement":"In the human HLCS assay, inhibitory potency ranked piceatannol above resveratrol above piceid.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e199e596-7363-5283-a62f-1c1c7d563727","mechanism_event_label":"Related compounds cannot be assigned identical potency.","subject":{"id":"e97a2145-03b2-5eef-b36b-4174536cd152","slug":"piceatannol","display_name":"Piceatannol","entity_type_key":"small_molecule"},"object":{"id":"31215c8f-3c76-5cba-bd32-a2bf7b4d3844","slug":"piceid","display_name":"Piceid / polydatin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"e199e596-7363-5283-a62f-1c1c7d563727","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-hlcs-forms-event","event_type":"observed_relationship","label":"Related compounds cannot be assigned identical potency.","description":"In the human HLCS assay, inhibitory potency ranked piceatannol above resveratrol above piceid.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e97a2145-03b2-5eef-b36b-4174536cd152","slug":"piceatannol","display_name":"Piceatannol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"31215c8f-3c76-5cba-bd32-a2bf7b4d3844","slug":"piceid","display_name":"Piceid / polydatin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"518c7af6-7e78-59ed-a9cb-3de53c9a39c8","slug":"hlcs","display_name":"Human holocarboxylase synthetase / HLCS","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified-compound enzyme comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not mean all are circulating resveratrol metabolites under a given regimen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Related compounds cannot be assigned identical potency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26303405/ · DOI 10.1016/j.jnutbio.2015.07.004","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"14596145-d791-5b7c-aa19-f65bfa64b7ab","evidence_kind":"source_excerpt","locator":"Lines 350-356","start_line":350,"end_line":356,"excerpt":"## resveratrol-hlcs-forms\nRelated compounds cannot be assigned identical potency.\nIn the human HLCS assay, inhibitory potency ranked piceatannol above resveratrol above piceid.\nModel: Purified-compound enzyme comparison.\nLimitations: Does not mean all are circulating resveratrol metabolites under a given regimen.\nEvidence access: Primary full text\nResveratrol compounds inhibit human holocarboxylase synthetase and cause a lean phenotype in Drosophila melanogaster. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26303405/ · DOI 10.1016/j.jnutbio.2015.07.004","model_system":"Purified-compound enzyme comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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