{"id":"bec76013-867e-51f8-90b1-cb800e5e1e54","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-fructoborate-inflammatory-markers","predicate":"reduces","statement":"The pilot reported improved CRP and other measured inflammatory markers with calcium fructoborate compared with placebo over about two weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f586a794-1f22-5054-bbba-e6467e15bb5d","mechanism_event_label":"The trial reported changes in blood markers; it did not show that damaged joints were rebuilt.","subject":{"id":"ff3117ce-4dba-59de-a41c-dd181a43c42c","slug":"calcium-fructoborate","display_name":"Calcium fructoborate","entity_type_key":"small_molecule"},"object":{"id":"ea0a3d14-17b9-5f68-98d1-07b246c42c6d","slug":"serum-crp-concentration","display_name":"Serum C-reactive protein concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f586a794-1f22-5054-bbba-e6467e15bb5d","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-fructoborate-inflammatory-markers-event","event_type":"observed_intervention","label":"The trial reported changes in blood markers; it did not show that damaged joints were rebuilt.","description":"The pilot reported improved CRP and other measured inflammatory markers with calcium fructoborate compared with placebo over about two weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ff3117ce-4dba-59de-a41c-dd181a43c42c","slug":"calcium-fructoborate","display_name":"Calcium fructoborate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ea0a3d14-17b9-5f68-98d1-07b246c42c6d","slug":"serum-crp-concentration","display_name":"Serum C-reactive protein concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/21607703.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"791318eaf72d7d13719549d6c655fa4023ebe6b5582776b785db1d403456a35d\", \"start_char\": 0, \"end_char\": 1236, \"text_sha256\": \"791318eaf72d7d13719549d6c655fa4023ebe6b5582776b785db1d403456a35d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled double-blind pilot in knee osteoarthritis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Approximately 15 days calcium-fructoborate supplementation; 116 recruited, 72 started and 60 completed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short pilot with attrition and biomarker outcomes; it does not establish cartilage repair, disease modification or equivalence of all boron compounds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial reported changes in blood markers; it did not show that damaged joints were rebuilt.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p21607703] A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. (2011). https://pubmed.ncbi.nlm.nih.gov/21607703/ DOI: 10.1007/s12011-011-9083-0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood inflammatory markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"26824432-d962-5ff3-9a1d-12b17db74158","evidence_kind":"source_excerpt","locator":"Lines 1054-1065","start_line":1054,"end_line":1065,"excerpt":"### boron-fructoborate-inflammatory-markers\nThe pilot reported improved CRP and other measured inflammatory markers with calcium fructoborate compared with placebo over about two weeks.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial reported changes in blood markers; it did not show that damaged joints were rebuilt.\norganism: Human\ntissue_or_cell_type: Blood inflammatory markers\nexperimental_model: Randomized placebo-controlled double-blind pilot in knee osteoarthritis\nlimitations: Short pilot with attrition and biomarker outcomes; it does not establish cartilage repair, disease modification or equivalence of all boron compounds.\nexposure: Approximately 15 days calcium-fructoborate supplementation; 116 recruited, 72 started and 60 completed\nevidence_span: {\"source_cache\": \"artifacts/boron-research/21607703.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"791318eaf72d7d13719549d6c655fa4023ebe6b5582776b785db1d403456a35d\", \"start_char\": 0, \"end_char\": 1236, \"text_sha256\": \"791318eaf72d7d13719549d6c655fa4023ebe6b5582776b785db1d403456a35d\"}\n[boron-p21607703] A double-blind, placebo-controlled pilot study to evaluate the effect of calcium fructoborate on systemic inflammation and dyslipidemia markers for middle-aged people with primary osteoarthritis. 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