{"id":"be92751a-870c-5da7-82c1-e356a14eff53","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-pdac-tumor-transporter","predicate":"reduces","statement":"Genetic SLC38A2 suppression impaired human PDAC tumor growth and the support provided by co-injected stellate cells in mouse xenograft experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"41cfd3cc-3a33-5280-9a21-057f7a0a0b53","mechanism_event_label":"A local nutrient-import dependency persisted in the animal tumor model.","subject":{"id":"ca39dc6d-6d6b-5398-af54-ad11cc9fa7c2","slug":"human-pdac-slc38a2-loss","display_name":"SLC38A2 loss in human PDAC cells","entity_type_key":"cellular_process"},"object":{"id":"d9875595-5789-5c85-a9e7-ccec4e2cbf06","slug":"human-pdac-xenograft-growth","display_name":"Human PDAC xenograft growth in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"41cfd3cc-3a33-5280-9a21-057f7a0a0b53","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-pdac-tumor-transporter-event","event_type":"observed_relationship","label":"A local nutrient-import dependency persisted in the animal tumor model.","description":"Genetic SLC38A2 suppression impaired human PDAC tumor growth and the support provided by co-injected stellate cells in mouse xenograft experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ca39dc6d-6d6b-5398-af54-ad11cc9fa7c2","slug":"human-pdac-slc38a2-loss","display_name":"SLC38A2 loss in human PDAC cells","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d9875595-5789-5c85-a9e7-ccec4e2cbf06","slug":"human-pdac-xenograft-growth","display_name":"Human PDAC xenograft growth in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d892d59f-d137-5a53-9b16-10e4b6732951","slug":"slc38a2","display_name":"Human sodium-coupled neutral amino acid transporter 2 / SLC38A2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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