{"id":"bd8b510c-05ad-561e-8d5d-892f92012459","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-genotype-human-insulin","predicate":"more_strongly_reduces_in_risk_carriers","statement":"The human recall-by-genotype study found greater insulin-secretion reduction and glucose elevation in G-allele carriers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"56343457-0d24-5213-9ec1-8c7fd11ac63c","mechanism_event_label":"A response can vary with receptor genotype.","subject":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"object":{"id":"7c50efe8-650e-5145-81ef-1c430510a538","slug":"insulin-secretion","display_name":"Insulin secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"56343457-0d24-5213-9ec1-8c7fd11ac63c","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-genotype-human-insulin-event","event_type":"observed_intervention","label":"A response can vary with receptor genotype.","description":"The human recall-by-genotype study found greater insulin-secretion reduction and glucose elevation in G-allele carriers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"526ce47e-7f2a-5544-892a-328fd788f4b7","slug":"mtnr1b-rs10830963-g","display_name":"Human MTNR1B rs10830963 G risk allele","entity_type_key":"gene"},"role":"genetic_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f0bc1f1-d18d-5652-bc1d-98f61f7ab65c","slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7c50efe8-650e-5145-81ef-1c430510a538","slug":"insulin-secretion","display_name":"Insulin secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/27185156.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"61fcf7c730c1349e5b306e5c9cfcabcb2905290d7f8762cbfba06f2b5fccaded\", \"start_char\": 0, \"end_char\": 1043, \"text_sha256\": \"61fcf7c730c1349e5b306e5c9cfcabcb2905290d7f8762cbfba06f2b5fccaded\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human islet genetics, cell experiments and recall-by-genotype intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Risk G allele, receptor overexpression and melatonin exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genotype associations, cultured-cell manipulation and human intervention are separate evidence types. Do not generalize islet signaling to every tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human islets and volunteers; separate insulin-cell and mouse experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A response can vary with receptor genotype.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p27185156] Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. (2016). https://pubmed.ncbi.nlm.nih.gov/27185156/ DOI: 10.1016/j.cmet.2016.04.009","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"MTNR1B signaling and insulin secretion","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ecbb86a4-9521-55a3-b376-1c676d400ec3","evidence_kind":"source_excerpt","locator":"Lines 1137-1148","start_line":1137,"end_line":1148,"excerpt":"### melatonin-genotype-human-insulin\nThe human recall-by-genotype study found greater insulin-secretion reduction and glucose elevation in G-allele carriers.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A response can vary with receptor genotype.\norganism: Human islets and volunteers; separate insulin-cell and mouse experiments\ntissue_or_cell_type: MTNR1B signaling and insulin secretion\nexperimental_model: Human islet genetics, cell experiments and recall-by-genotype intervention\nlimitations: Genotype associations, cultured-cell manipulation and human intervention are separate evidence types. Do not generalize islet signaling to every tissue.\nexposure: Risk G allele, receptor overexpression and melatonin exposure\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/27185156.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"61fcf7c730c1349e5b306e5c9cfcabcb2905290d7f8762cbfba06f2b5fccaded\", \"start_char\": 0, \"end_char\": 1043, \"text_sha256\": \"61fcf7c730c1349e5b306e5c9cfcabcb2905290d7f8762cbfba06f2b5fccaded\"}\n[melatonin-p27185156] Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. (2016). https://pubmed.ncbi.nlm.nih.gov/27185156/ DOI: 10.1016/j.cmet.2016.04.009","model_system":"Human islet genetics, cell experiments and recall-by-genotype intervention","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p27185156] Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. (2016). https://pubmed.ncbi.nlm.nih.gov/27185156/ DOI: 10.1016/j.cmet.2016.04.009","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff4f279d263f95a69da8e7e8a6c6318ab6ba1b55254dbbda1bfa9ce437e1db80","revision_id":"0318eef8-ff38-513e-8ffa-458146ca5e77","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}