{"id":"bd7b6d1d-4347-528c-9af7-f0e694b44626","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:low-magnesium-diet-without-hypomagnesemia","predicate":"influences","statement":"Mg biomarkers declined on the low-Mg diet, but hypomagnesemia, hypocalcemia and hypokalemia were not detected.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"79681f98-8bcd-5484-a9bd-da7992187440","mechanism_event_label":"A normal-range serum result did not rule out the diet-related electrical phenotype in these participants.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"623a99ab-787c-5d78-8072-72cfcd82008e","slug":"serum-magnesium-concentration","display_name":"Serum magnesium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"79681f98-8bcd-5484-a9bd-da7992187440","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:low-magnesium-diet-without-hypomagnesemia-event","event_type":"observed_intervention","label":"A normal-range serum result did not rule out the diet-related electrical phenotype in these participants.","description":"Mg biomarkers declined on the low-Mg diet, but hypomagnesemia, hypocalcemia and hypokalemia were not detected.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"measured-ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"role":"nondeficient-comparator","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a50139de-7ee0-5916-9839-465102c43813","slug":"supraventricular-ectopy","display_name":"Supraventricular ectopy","entity_type_key":"cellular_process"},"role":"concurrent-electrical-endpoint","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"623a99ab-787c-5d78-8072-72cfcd82008e","slug":"serum-magnesium-concentration","display_name":"Serum magnesium concentration","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence-system","value_text":"Crossover feeding and biochemical monitoring","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Crossover feeding and biochemical monitoring","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chemically measured mean intake: 130 mg Mg/day in the low period versus 411 mg/day in the supplemented period; 81 days per period after 10-day equilibration. These are experimental exposures, not recommendations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A study-specific biomarker observation; not a diagnostic rule for all normal serum values.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A normal-range serum result did not rule out the diet-related electrical phenotype in these participants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[klevay-2002-ectopy] Low dietary magnesium increases supraventricular ectopy (2002). https://ajcn.nutrition.org/article/S0002-9165%2823%2906154-3/fulltext DOI: 10.1093/ajcn/75.3.550","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Serum, erythrocytes and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum, erythrocytes and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"59f02250-b93b-5b4a-9145-ba552b929eca","evidence_kind":"source_excerpt","locator":"Lines 1332-1344","start_line":1332,"end_line":1344,"excerpt":"### low-magnesium-diet-without-hypomagnesemia\nMg biomarkers declined on the low-Mg diet, but hypomagnesemia, hypocalcemia and hypokalemia were not detected.\nCondition category: biomarker_context\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A normal-range serum result did not rule out the diet-related electrical phenotype in these participants.\norganism: Human\ntissue_or_cell_type: Serum, erythrocytes and urine\nexperimental_model: Crossover feeding and biochemical monitoring\nlimitations: A study-specific biomarker observation; not a diagnostic rule for all normal serum values.\nexposure: Chemically measured mean intake: 130 mg Mg/day in the low period versus 411 mg/day in the supplemented period; 81 days per period after 10-day equilibration. These are experimental exposures, not recommendations.\nevidence-system: Crossover feeding and biochemical monitoring\ntissue: Serum, erythrocytes and urine\n[klevay-2002-ectopy] Low dietary magnesium increases supraventricular ectopy (2002). https://ajcn.nutrition.org/article/S0002-9165%2823%2906154-3/fulltext DOI: 10.1093/ajcn/75.3.550","model_system":"Crossover feeding and biochemical monitoring","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [klevay-2002-ectopy] Low dietary magnesium increases supraventricular ectopy (2002). https://ajcn.nutrition.org/article/S0002-9165%2823%2906154-3/fulltext DOI: 10.1093/ajcn/75.3.550","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}