{"id":"bd57d26b-ae15-565d-96b9-36019ef3eb44","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-microbial-glucoside-selectivity","predicate":"has_position_selective_degradation","statement":"E. ramulus degraded luteolin 7-glucoside but not luteolin 5-glucoside under the tested anaerobic conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"db055e3f-e213-5095-a249-1f461f4c085f","mechanism_event_label":"Changing sugar position changed bacterial access.","subject":{"id":"5b74d97d-93aa-5a34-95f1-e90b14b2e7eb","slug":"eubacterium-ramulus-wk1","display_name":"Eubacterium ramulus strain wK1","entity_type_key":"organism"},"object":{"id":"47b0cd22-95db-58d3-87e2-2c07c883a804","slug":"luteolin-7-o-glucoside","display_name":"Luteolin 7-O-glucoside","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"db055e3f-e213-5095-a249-1f461f4c085f","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-microbial-glucoside-selectivity-event","event_type":"observed_relationship","label":"Changing sugar position changed bacterial access.","description":"E. ramulus degraded luteolin 7-glucoside but not luteolin 5-glucoside under the tested anaerobic conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5b74d97d-93aa-5a34-95f1-e90b14b2e7eb","slug":"eubacterium-ramulus-wk1","display_name":"Eubacterium ramulus strain wK1","entity_type_key":"organism"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"47b0cd22-95db-58d3-87e2-2c07c883a804","slug":"luteolin-7-o-glucoside","display_name":"Luteolin 7-O-glucoside","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d20ac893-6e21-5334-b2e7-422acec9afe7","slug":"luteolin-5-o-glucoside","display_name":"Luteolin 5-O-glucoside","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Bacterial substrate-degradation study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that all gut communities behave identically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Changing sugar position changed bacterial access.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Anaerobic degradation of flavonoids by Eubacterium ramulus. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10648107/ · DOI 10.1007/s002030050010","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d1c52439-493e-5e09-ae37-08117964143f","evidence_kind":"source_excerpt","locator":"Lines 268-274","start_line":268,"end_line":274,"excerpt":"## luteolin-microbial-glucoside-selectivity\nChanging sugar position changed bacterial access.\nE. ramulus degraded luteolin 7-glucoside but not luteolin 5-glucoside under the tested anaerobic conditions.\nModel: Bacterial substrate-degradation study.\nLimitations: Not evidence that all gut communities behave identically.\nEvidence access: Primary abstract\nAnaerobic degradation of flavonoids by Eubacterium ramulus. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10648107/ · DOI 10.1007/s002030050010","model_system":"Bacterial substrate-degradation study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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