{"id":"bd527cf0-df06-5273-9f17-ba1957b2a05d","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-intestinal-secretion","predicate":"increases","statement":"Mangiferin promoted endogenous urate secretion into mouse intestinal loops.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"48a75da2-f6d1-55ac-b9c6-019ce2488b85","mechanism_event_label":"The intestine is another measured route of urate elimination.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"8abc449c-88c8-5da4-a923-280d06c83609","slug":"mouse-intestinal-urate-secretion","display_name":"Mouse intestinal urate secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"48a75da2-f6d1-55ac-b9c6-019ce2488b85","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-intestinal-secretion-event","event_type":"biochemical_relationship","label":"The intestine is another measured route of urate elimination.","description":"Mangiferin promoted endogenous urate secretion into mouse intestinal loops.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8abc449c-88c8-5da4-a923-280d06c83609","slug":"mouse-intestinal-urate-secretion","display_name":"Mouse intestinal urate secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/32827538.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958\", \"start_char\": 0, \"end_char\": 1796, \"text_sha256\": \"96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rodent intestinal-loop secretion/absorption experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin in normal and hyperuricemic loop experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression association does not establish direct binding; intestinal effects need not mirror kidney effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mice for secretion/proteins; rats for absorption","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The intestine is another measured route of urate elimination.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p32827538] Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. (2020). https://pubmed.ncbi.nlm.nih.gov/32827538/ DOI: 10.1016/j.ejphar.2020.173490","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9698be48-9c24-5bb5-86c7-0ab8b39e5229","evidence_kind":"source_excerpt","locator":"Lines 1082-1093","start_line":1082,"end_line":1093,"excerpt":"### mangiferin-intestinal-secretion\nMangiferin promoted endogenous urate secretion into mouse intestinal loops.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The intestine is another measured route of urate elimination.\norganism: Mice for secretion/proteins; rats for absorption\ntissue_or_cell_type: Intestine\nexperimental_model: Rodent intestinal-loop secretion/absorption experiments\nlimitations: Expression association does not establish direct binding; intestinal effects need not mirror kidney effects.\nexposure: Mangiferin in normal and hyperuricemic loop experiments\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/32827538.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958\", \"start_char\": 0, \"end_char\": 1796, \"text_sha256\": \"96aea91b79bcbc9d1f63f83c0bda025138e3b97f3f7657b56149c9cc3e0e5958\"}\n[mangiferin-p32827538] Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. (2020). https://pubmed.ncbi.nlm.nih.gov/32827538/ DOI: 10.1016/j.ejphar.2020.173490","model_system":"Rodent intestinal-loop secretion/absorption experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p32827538] Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. (2020). https://pubmed.ncbi.nlm.nih.gov/32827538/ DOI: 10.1016/j.ejphar.2020.173490","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"295cb3a13742b3caeed19347ffcbc7863f5372d983da1625a942428919b4dc98","revision_id":"d9c2ee89-ff22-5e86-9d7f-7cb7e17f9ed2","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}