{"id":"bd3ec95b-6d11-5365-9d8a-7789808d813a","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-gsh-hne","predicate":"reacts_with","statement":"Glutathione reacted more readily than carnosine with HNE in the comparative assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a2241f55-fd8f-563f-b957-45d6ef330a2e","mechanism_event_label":"The preferred scavenger changed with the target molecule.","subject":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"object":{"id":"cc9bce9d-a834-5e6d-85a5-b873b8e69a21","slug":"4-hydroxynonenal","display_name":"4-Hydroxy-2-nonenal / HNE","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"a2241f55-fd8f-563f-b957-45d6ef330a2e","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-gsh-hne-event","event_type":"observed_relationship","label":"The preferred scavenger changed with the target molecule.","description":"Glutathione reacted more readily than carnosine with HNE in the comparative assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cc9bce9d-a834-5e6d-85a5-b873b8e69a21","slug":"4-hydroxynonenal","display_name":"4-Hydroxy-2-nonenal / HNE","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same biochemical study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Context difference from DOPAL chemistry, not a contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The preferred scavenger changed with the target molecule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30191330/ · DOI 10.1007/s00726-018-2647-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6cdf0b36-157a-5147-a631-ef53e424c628","evidence_kind":"source_excerpt","locator":"Lines 284-290","start_line":284,"end_line":290,"excerpt":"## carnosine-gsh-hne\nThe preferred scavenger changed with the target molecule.\nGlutathione reacted more readily than carnosine with HNE in the comparative assay.\nModel: Same biochemical study.\nLimitations: Context difference from DOPAL chemistry, not a contradiction.\nEvidence access: Primary abstract\nBiochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30191330/ · DOI 10.1007/s00726-018-2647-y","model_system":"Same biochemical study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}