{"id":"bd360775-ea92-5f7b-b770-104473035f01","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-maternal-processing","predicate":"reduces","statement":"Mean infant reaction time across the four assessment ages was faster in the 930-versus-480 mg/day maternal group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"622bd383-ec2b-5496-a167-06acbaf8814d","mechanism_event_label":"The higher-intake group showed a benefit on this particular infant processing-speed measure.","subject":{"id":"dc61a945-03d6-55e9-9cac-db0a0a8e58bc","slug":"maternal-choline-930-480","display_name":"Maternal 930-versus-480 mg/day choline controlled-feeding intervention","entity_type_key":"chemical_species"},"object":{"id":"b24487e5-7266-58d6-ae9a-7736ed0220b5","slug":"infant-saccade-reaction-time","display_name":"Infant saccade reaction time in the 2018 maternal-feeding trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"622bd383-ec2b-5496-a167-06acbaf8814d","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-maternal-processing-event","event_type":"observed_intervention","label":"The higher-intake group showed a benefit on this particular infant processing-speed measure.","description":"Mean infant reaction time across the four assessment ages was faster in the 930-versus-480 mg/day maternal group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc61a945-03d6-55e9-9cac-db0a0a8e58bc","slug":"maternal-choline-930-480","display_name":"Maternal 930-versus-480 mg/day choline controlled-feeding intervention","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b24487e5-7266-58d6-ae9a-7736ed0220b5","slug":"infant-saccade-reaction-time","display_name":"Infant saccade reaction time in the 2018 maternal-feeding trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/29217669.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d5062bfc0f04b936cad236302e998e3db8bbcd9bb6c106f6cff748e513799d01\", \"start_char\": 0, \"end_char\": 1693, \"text_sha256\": \"d5062bfc0f04b936cad236302e998e3db8bbcd9bb6c106f6cff748e513799d01\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind controlled maternal feeding and infant follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"480 versus 930 mg total choline/day in the third trimester; infant testing at 4, 7, 10 and 13 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small trial with a specific processing-speed endpoint. Not a general intelligence claim or proof that every pregnancy benefits equally.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Choline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The higher-intake group showed a benefit on this particular infant processing-speed measure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[choline-p29217669] Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. (2018). https://pubmed.ncbi.nlm.nih.gov/29217669/ DOI: 10.1096/fj.201700692rr","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"26 randomized pregnant women; 24 infants assessed","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3eaf062f-39e2-58a9-8c0c-c3decadcc700","evidence_kind":"source_excerpt","locator":"Lines 1257-1268","start_line":1257,"end_line":1268,"excerpt":"### choline-maternal-processing\nMean infant reaction time across the four assessment ages was faster in the 930-versus-480 mg/day maternal group.\nCondition category: normal\nnutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The higher-intake group showed a benefit on this particular infant processing-speed measure.\norganism: Human\ntissue_or_cell_type: 26 randomized pregnant women; 24 infants assessed\nexperimental_model: Randomized double-blind controlled maternal feeding and infant follow-up\nlimitations: Small trial with a specific processing-speed endpoint. Not a general intelligence claim or proof that every pregnancy benefits equally.\nexposure: 480 versus 930 mg total choline/day in the third trimester; infant testing at 4, 7, 10 and 13 months\nevidence_span: {\"source_cache\": \"artifacts/choline-research/29217669.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d5062bfc0f04b936cad236302e998e3db8bbcd9bb6c106f6cff748e513799d01\", \"start_char\": 0, \"end_char\": 1693, \"text_sha256\": \"d5062bfc0f04b936cad236302e998e3db8bbcd9bb6c106f6cff748e513799d01\"}\n[choline-p29217669] Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. (2018). https://pubmed.ncbi.nlm.nih.gov/29217669/ DOI: 10.1096/fj.201700692rr","model_system":"Randomized double-blind controlled maternal feeding and infant follow-up","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [choline-p29217669] Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study. (2018). https://pubmed.ncbi.nlm.nih.gov/29217669/ DOI: 10.1096/fj.201700692rr","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0ba2f05e-5cf5-5bd7-ae5d-0ab4945fcb7b","stable_key":"import-27e0c1cf-7726-5164-8b15-27a631584cd0","title":"Choline: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"c7afe3d579eba0df6d2a4c26699c653462749e03188348f900c07748cc7282a8","revision_id":"0fa7b48f-2a3c-5adc-b13e-48727dd6f815","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}