{"id":"bd1c7a51-b717-5024-b05b-ab995e255308","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-low-diet-glucose-null-2011","predicate":"low_intake_did_not_change","statement":"The six-month low-chromium diet did not alter glucose responses in glucose- or insulin-tolerance tests relative to the standard diet.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"20a8ba26-4015-5edd-a63e-38e054274b14","mechanism_event_label":"The rats did not develop the expected glucose-control defect in this carefully controlled model.","subject":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"object":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"20a8ba26-4015-5edd-a63e-38e054274b14","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-low-diet-glucose-null-2011-event","event_type":"observed_intervention","label":"The rats did not develop the expected glucose-control defect in this carefully controlled model.","description":"The six-month low-chromium diet did not alter glucose responses in glucose- or insulin-tolerance tests relative to the standard diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b0fcea7a-0388-5f63-b7bb-38817cd5924f","slug":"glucose-tolerance","display_name":"Glucose tolerance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/21086001.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"308018cb4483d2b09c61c09f63a45811cc801750fd4f7922b8c9f010f5165abd\", \"start_char\": 0, \"end_char\": 1561, \"text_sha256\": \"308018cb4483d2b09c61c09f63a45811cc801750fd4f7922b8c9f010f5165abd\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six-month metal-controlled low-chromium feeding experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"AIN-93G with no added chromium versus standard diet and supplemental 200 or 1,000 µg Cr/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Low intake is not absolute zero exposure. Lack of abnormality in this rat model challenges essentiality claims but is not by itself a complete human requirement experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Male Zucker lean rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The rats did not develop the expected glucose-control defect in this carefully controlled model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p21086001] Chromium is not an essential trace element for mammals: effects of a \"low-chromium\" diet. (2011). https://pubmed.ncbi.nlm.nih.gov/21086001/ DOI: 10.1007/s00775-010-0734-y","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Body composition and glucose/insulin tolerance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d6142c48-4937-5ef3-a998-04c956644f55","evidence_kind":"source_excerpt","locator":"Lines 952-963","start_line":952,"end_line":963,"excerpt":"### chromium-low-diet-glucose-null-2011\nThe six-month low-chromium diet did not alter glucose responses in glucose- or insulin-tolerance tests relative to the standard diet.\nCondition category: nutrient_deficiency\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The rats did not develop the expected glucose-control defect in this carefully controlled model.\norganism: Male Zucker lean rats\ntissue_or_cell_type: Body composition and glucose/insulin tolerance\nexperimental_model: Six-month metal-controlled low-chromium feeding experiment\nlimitations: Low intake is not absolute zero exposure. Lack of abnormality in this rat model challenges essentiality claims but is not by itself a complete human requirement experiment.\nexposure: AIN-93G with no added chromium versus standard diet and supplemental 200 or 1,000 µg Cr/kg\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/21086001.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"308018cb4483d2b09c61c09f63a45811cc801750fd4f7922b8c9f010f5165abd\", \"start_char\": 0, \"end_char\": 1561, \"text_sha256\": \"308018cb4483d2b09c61c09f63a45811cc801750fd4f7922b8c9f010f5165abd\"}\n[chromium-p21086001] Chromium is not an essential trace element for mammals: effects of a \"low-chromium\" diet. 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