{"id":"bcb7d44f-3be4-5dc1-a3e8-b2421a16df84","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-cd36-adipocyte","predicate":"supports","statement":"CD36 inhibition or partial knockdown reduced lycopene uptake in 3T3-L1 adipocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"92aa31ac-7552-5df5-8be6-8b1a28057771","mechanism_event_label":"Fat cells have uptake machinery for lycopene too.","subject":{"id":"98f1fe60-4f89-5d3f-830a-d1f61988a90c","slug":"mouse-cd36","display_name":"Mouse fatty-acid translocase / Cd36","entity_type_key":"protein"},"object":{"id":"0afc8a31-29ba-5f5f-b10e-f8b971f09710","slug":"adipocyte-lycopene-uptake","display_name":"Lycopene uptake by adipocytes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"92aa31ac-7552-5df5-8be6-8b1a28057771","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-cd36-adipocyte-event","event_type":"biochemical_relationship","label":"Fat cells have uptake machinery for lycopene too.","description":"CD36 inhibition or partial knockdown reduced lycopene uptake in 3T3-L1 adipocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"transported_carotenoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"98f1fe60-4f89-5d3f-830a-d1f61988a90c","slug":"mouse-cd36","display_name":"Mouse fatty-acid translocase / Cd36","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0afc8a31-29ba-5f5f-b10e-f8b971f09710","slug":"adipocyte-lycopene-uptake","display_name":"Lycopene uptake by adipocytes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/21462325.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"de4990e5a9c520e6e528e181a4e81a469a4ebac313151bfa7828ad935b04a823\", \"start_char\": 0, \"end_char\": 1048, \"text_sha256\": \"de4990e5a9c520e6e528e181a4e81a469a4ebac313151bfa7828ad935b04a823\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Transport inhibition, siRNA, overexpression and knockout explants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"CD36 inhibitor, partial knockdown and Cd36-null tissue","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not relabel adipose results as intestinal uptake or a clinical human transport-deficiency syndrome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mouse 3T3-L1 adipocytes and mouse adipose explants; COS-1 expression experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Fat cells have uptake machinery for lycopene too.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p21462325] CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures. 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