{"id":"bcaa883b-8d1d-53db-be5e-33a909c80bef","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-restriction-microbial-sulfur","predicate":"reduces_tested","statement":"Methionine restriction reduced microbial hydrogen-sulfide production and impaired immune-cell survival/activation in the study models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"15411ea9-3242-58f8-b4ab-4521cbe112cf","mechanism_event_label":"Dietary sulfur supply also changes support coming from gut microbes.","subject":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"object":{"id":"fc01714a-bcec-58d1-86c5-d06ac19a1bda","slug":"mouse-gut-microbial-hydrogen-sulfide","display_name":"Gut microbial hydrogen-sulfide production in the MR tumor study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"15411ea9-3242-58f8-b4ab-4521cbe112cf","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-restriction-microbial-sulfur-event","event_type":"observed_relationship","label":"Dietary sulfur supply also changes support coming from gut microbes.","description":"Methionine restriction reduced microbial hydrogen-sulfide production and impaired immune-cell survival/activation in the study models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fc01714a-bcec-58d1-86c5-d06ac19a1bda","slug":"mouse-gut-microbial-hydrogen-sulfide","display_name":"Gut microbial hydrogen-sulfide production in the MR tumor study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Immunocompetent male/female mouse tumor models with microbiome and sulfur interventions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Microbial sulfur production is not identical to host CBS/CTH flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Dietary sulfur supply also changes support coming from gut microbes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"729c329e-42a5-5921-8050-4f66b5cce67c","evidence_kind":"source_excerpt","locator":"Lines 460-466","start_line":460,"end_line":466,"excerpt":"## methionine-restriction-microbial-sulfur\nDietary sulfur supply also changes support coming from gut microbes.\nMethionine restriction reduced microbial hydrogen-sulfide production and impaired immune-cell survival/activation in the study models.\nModel: Immunocompetent male/female mouse tumor models with microbiome and sulfur interventions.\nLimitations: Microbial sulfur production is not identical to host CBS/CTH flux.\nEvidence access: Primary abstract\nMethionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37537369/ · DOI 10.1038/s42255-023-00854-3","model_system":"Immunocompetent male/female mouse tumor models with microbiome and sulfur interventions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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