{"id":"bbffbebb-2699-5beb-b353-bd393104c19c","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-oat-reaction","predicate":"transaminated_to","statement":"OAT transfers the ornithine delta-amino group to 2-oxoglutarate, producing glutamate-5-semialdehyde and glutamate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8e59c66d-94b7-5b29-bd6e-d39ee4e13a47","mechanism_event_label":"Ornithine also feeds a pathway connected to proline metabolism.","subject":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"object":{"id":"33e6c1dc-af9c-5ec6-8e23-6c15bff974f5","slug":"glutamate-5-semialdehyde","display_name":"L-Glutamate-5-semialdehyde","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8e59c66d-94b7-5b29-bd6e-d39ee4e13a47","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-oat-reaction-event","event_type":"observed_relationship","label":"Ornithine also feeds a pathway connected to proline metabolism.","description":"OAT transfers the ornithine delta-amino group to 2-oxoglutarate, producing glutamate-5-semialdehyde and glutamate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"33e6c1dc-af9c-5ec6-8e23-6c15bff974f5","slug":"glutamate-5-semialdehyde","display_name":"L-Glutamate-5-semialdehyde","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ddcb770b-d815-5f25-b055-f1f15174140e","slug":"oat","display_name":"Human ornithine aminotransferase / OAT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"628ddc2d-e4d9-59c7-ae76-0c0cab80a6b1","slug":"2-oxoglutarate","display_name":"2-Oxoglutarate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human OAT structure and described catalytic reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reversible pathway; net flux depends on tissue and substrate conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Ornithine also feeds a pathway connected to proline metabolism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Crystal structure of human recombinant ornithine aminotransferase. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9514741/ · DOI 10.1006/jmbi.1997.1583","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"668618d0-a7fa-5dea-9cf0-40273c2e0474","evidence_kind":"source_excerpt","locator":"Lines 118-124","start_line":118,"end_line":124,"excerpt":"## arg-oat-reaction\nOrnithine also feeds a pathway connected to proline metabolism.\nOAT transfers the ornithine delta-amino group to 2-oxoglutarate, producing glutamate-5-semialdehyde and glutamate.\nModel: Recombinant human OAT structure and described catalytic reaction.\nLimitations: Reversible pathway; net flux depends on tissue and substrate conditions.\nEvidence access: Primary abstract\nCrystal structure of human recombinant ornithine aminotransferase. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9514741/ · DOI 10.1006/jmbi.1997.1583","model_system":"Recombinant human OAT structure and described catalytic reaction.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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