{"id":"bbdf732a-7228-5400-9680-f682e54543ad","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-stress-heart-rate","predicate":"attenuates","statement":"Theanine reduced the heart-rate response to the laboratory stress task.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"03b7bba9-8110-5eb6-88b1-b814b840aa78","mechanism_event_label":"An acute physiological response was measured, not a diagnosis or long-term treatment effect.","subject":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"object":{"id":"6bcf6700-afc1-5a85-99c9-07e9619afcda","slug":"acute-stress-heart-rate-response","display_name":"Heart-rate response to acute psychological stress","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"03b7bba9-8110-5eb6-88b1-b814b840aa78","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-stress-heart-rate-event","event_type":"observed_intervention","label":"An acute physiological response was measured, not a diagnosis or long-term treatment effect.","description":"Theanine reduced the heart-rate response to the laboratory stress task.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6bcf6700-afc1-5a85-99c9-07e9619afcda","slug":"acute-stress-heart-rate-response","display_name":"Heart-rate response to acute psychological stress","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/16930802.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"31dbb84c1297b65782bcb68a3408ca09cfeaf9e43ce03503303e1596bd2fe834\", \"start_char\": 0, \"end_char\": 1257, \"text_sha256\": \"31dbb84c1297b65782bcb68a3408ca09cfeaf9e43ce03503303e1596bd2fe834\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Acute laboratory mental-stress experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Theanine before mental arithmetic stress","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small experimental stress study. Sympathetic modulation was inferred; direct receptor mechanism was not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"12 humans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An acute physiological response was measured, not a diagnosis or long-term treatment effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p16930802] L-Theanine reduces psychological and physiological stress responses. (2007). https://pubmed.ncbi.nlm.nih.gov/16930802/ DOI: 10.1016/j.biopsycho.2006.06.006","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Heart rate and salivary immunoglobulin A","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e7feaaf5-4c9a-5a17-8c99-74005c5216e4","evidence_kind":"source_excerpt","locator":"Lines 1056-1067","start_line":1056,"end_line":1067,"excerpt":"### theanine-stress-heart-rate\nTheanine reduced the heart-rate response to the laboratory stress task.\nCondition category: normal\nnutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An acute physiological response was measured, not a diagnosis or long-term treatment effect.\norganism: 12 humans\ntissue_or_cell_type: Heart rate and salivary immunoglobulin A\nexperimental_model: Acute laboratory mental-stress experiment\nlimitations: Small experimental stress study. Sympathetic modulation was inferred; direct receptor mechanism was not established.\nexposure: Theanine before mental arithmetic stress\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/16930802.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"31dbb84c1297b65782bcb68a3408ca09cfeaf9e43ce03503303e1596bd2fe834\", \"start_char\": 0, \"end_char\": 1257, \"text_sha256\": \"31dbb84c1297b65782bcb68a3408ca09cfeaf9e43ce03503303e1596bd2fe834\"}\n[theanine-p16930802] L-Theanine reduces psychological and physiological stress responses. (2007). https://pubmed.ncbi.nlm.nih.gov/16930802/ DOI: 10.1016/j.biopsycho.2006.06.006","model_system":"Acute laboratory mental-stress experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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