{"id":"bbd9a251-a89f-5057-ad51-3bf016499289","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-lysosome-damage","predicate":"induces","statement":"Phagocytosed silica caused lysosomal swelling and leakage in mouse macrophages.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fff303d7-8d01-57f4-a558-eb4043bb0d8e","mechanism_event_label":"Particles can damage the compartment that engulfs them.","subject":{"id":"b2d4231b-3893-5d4e-8b52-d0effdaa26c9","slug":"crystalline-silica","display_name":"Crystalline silica / quartz particles","entity_type_key":"chemical_species"},"object":{"id":"21e1d702-d09b-5bca-a3c6-3ca1fb27c3d8","slug":"mouse-silica-lysosomal-permeabilization","display_name":"Lysosomal permeabilization in silica-exposed mouse macrophages","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fff303d7-8d01-57f4-a558-eb4043bb0d8e","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-lysosome-damage-event","event_type":"observed_relationship","label":"Particles can damage the compartment that engulfs them.","description":"Phagocytosed silica caused lysosomal swelling and leakage in mouse macrophages.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b2d4231b-3893-5d4e-8b52-d0effdaa26c9","slug":"crystalline-silica","display_name":"Crystalline silica / quartz particles","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"21e1d702-d09b-5bca-a3c6-3ca1fb27c3d8","slug":"mouse-silica-lysosomal-permeabilization","display_name":"Lysosomal permeabilization in silica-exposed mouse macrophages","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse macrophage imaging of vesicular cargo redistribution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Particle preparation and cellular priming matter. Correction record: A 2026 author correction replaces an erroneously duplicated lower-left Fig. 8c micrograph with the retrieved original. This is a figure correction, not a scientific contradiction or retraction. https://www.nature.com/articles/s41590-026-02468-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Particles can damage the compartment that engulfs them.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18604214/ · DOI 10.1038/ni.1631","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3e5b2d98-ceb3-5c27-863e-872ae9b593a1","evidence_kind":"source_excerpt","locator":"Lines 424-430","start_line":424,"end_line":430,"excerpt":"## silica-lysosome-damage\nParticles can damage the compartment that engulfs them.\nPhagocytosed silica caused lysosomal swelling and leakage in mouse macrophages.\nModel: Mouse macrophage imaging of vesicular cargo redistribution.\nLimitations: Particle preparation and cellular priming matter. Correction record: A 2026 author correction replaces an erroneously duplicated lower-left Fig. 8c micrograph with the retrieved original. This is a figure correction, not a scientific contradiction or retraction. https://www.nature.com/articles/s41590-026-02468-9\nEvidence access: Primary full text\nSilica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18604214/ · DOI 10.1038/ni.1631","model_system":"Mouse macrophage imaging of vesicular cargo redistribution.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}