{"id":"bbcede32-0294-5d54-a442-43b782572749","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-chronic-loss-aging","predicate":"restrains_tested","statement":"Persistent D-aspartate elevation after Ddo deletion accompanied increased extracellular glutamate, active caspases, reactive glia and age-dependent brain abnormalities.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"885761d4-3e9b-529c-ab81-649eb6e0ef51","mechanism_event_label":"Long-term loss of clearance had adverse outcomes despite some short-term signaling effects.","subject":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"object":{"id":"c855c7fe-2ea2-5b5e-8d2a-4094bcbcbe3b","slug":"mouse-ddo-loss-aging-pathology","display_name":"Age-dependent brain pathology after mouse Ddo deletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"885761d4-3e9b-529c-ab81-649eb6e0ef51","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-chronic-loss-aging-event","event_type":"observed_relationship","label":"Long-term loss of clearance had adverse outcomes despite some short-term signaling effects.","description":"Persistent D-aspartate elevation after Ddo deletion accompanied increased extracellular glutamate, active caspases, reactive glia and age-dependent brain abnormalities.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c855c7fe-2ea2-5b5e-8d2a-4094bcbcbe3b","slug":"mouse-ddo-loss-aging-pathology","display_name":"Age-dependent brain pathology after mouse Ddo deletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"0dfaac36-ded6-5591-bacc-aef6e58b1135","slug":"mouse-nmda-receptors","display_name":"Mouse NMDA-type receptors, subunits unresolved","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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