{"id":"bba3baee-f72b-5d77-aeff-98e6133e3943","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-tau-disassembly","predicate":"alters_preformed","statement":"Exposure altered preformed tau fibrils, including shorter filaments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9be07c2c-0830-5bd0-861a-0c6f6dca6cca","mechanism_event_label":"Already formed fibrils changed in the assay.","subject":{"id":"abe017d6-85cd-598c-91b3-3f5b4b87c543","slug":"tau-fulvic-preparation-2011","display_name":"Fulvic preparation in 2011 tau study, identity unresolved here","entity_type_key":"chemical_species"},"object":{"id":"653b0b2b-dc74-5c8c-9162-c0b1b2c358c9","slug":"tau-preformed-phf-morphology","display_name":"Preformed tau paired-helical-filament length and morphology","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9be07c2c-0830-5bd0-861a-0c6f6dca6cca","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-tau-disassembly-event","event_type":"observed_relationship","label":"Already formed fibrils changed in the assay.","description":"Exposure altered preformed tau fibrils, including shorter filaments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"abe017d6-85cd-598c-91b3-3f5b4b87c543","slug":"tau-fulvic-preparation-2011","display_name":"Fulvic preparation in 2011 tau study, identity unresolved here","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"653b0b2b-dc74-5c8c-9162-c0b1b2c358c9","slug":"tau-preformed-phf-morphology","display_name":"Preformed tau paired-helical-filament length and morphology","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0aa6c0fc-8374-56e0-b172-6c40b6366d21","slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e6e12feb-ecfe-5217-8cfd-5184a502cceb","slug":"mapt","display_name":"Human microtubule-associated protein tau / MAPT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free atomic-force microscopy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Proposed hydrophobic interaction is not a verified binding site; smaller structures need not be non-toxic.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fulvic acid collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Already formed fibrils changed in the assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21785188/ · DOI 10.3233/JAD-2011-110623","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"504d6dc1-4f9e-537f-a817-78fbac5fa42b","evidence_kind":"source_excerpt","locator":"Lines 156-162","start_line":156,"end_line":162,"excerpt":"## fulvic-acid-tau-disassembly\nAlready formed fibrils changed in the assay.\nExposure altered preformed tau fibrils, including shorter filaments.\nModel: Cell-free atomic-force microscopy.\nLimitations: Proposed hydrophobic interaction is not a verified binding site; smaller structures need not be non-toxic.\nEvidence access: Primary abstract\nFulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21785188/ · DOI 10.3233/JAD-2011-110623","model_system":"Cell-free atomic-force microscopy.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b00a1818-46e4-52cc-8dfe-a647d5c08ed7","stable_key":"import-788beb7b-7928-5f89-83d4-5556abf3702c","title":"Fulvic acid: mixture identity, mineral chemistry, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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