{"id":"bb1df076-05da-5e5d-a075-3526109c0817","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-preterm-sodium","predicate":"supplementation_reduces_low","statement":"Supplemented preterm infants had fewer recorded serum sodium values below 135 mmol/L.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cfeed7bd-e07b-542f-8772-69e026d2865d","mechanism_event_label":"Very premature infants can need a different sodium provision than older children or adults.","subject":{"id":"0e4aaa90-5b94-5d69-ba79-d760da4e0268","slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"},"object":{"id":"da7ca55c-2632-5eb7-b91c-94885c90d27e","slug":"plasma-sodium-concentration","display_name":"Plasma or serum sodium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cfeed7bd-e07b-542f-8772-69e026d2865d","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-preterm-sodium-event","event_type":"observed_intervention","label":"Very premature infants can need a different sodium provision than older children or adults.","description":"Supplemented preterm infants had fewer recorded serum sodium values below 135 mmol/L.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e4aaa90-5b94-5d69-ba79-d760da4e0268","slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"da7ca55c-2632-5eb7-b91c-94885c90d27e","slug":"plasma-sodium-concentration","display_name":"Plasma or serum sodium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/25406227.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a3c6cd28e4896dc8cdaeaacb7d524c55098b87dd5bf9d028ce49ba544832e339\", \"start_char\": 0, \"end_char\": 1645, \"text_sha256\": \"a3c6cd28e4896dc8cdaeaacb7d524c55098b87dd5bf9d028ce49ba544832e339\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized masked trial in 53 infants born before 32 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"4 mEq/kg/day supplemental sodium versus placebo, days 7–35","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study regimen, not a dosing recommendation. 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(2016). https://pubmed.ncbi.nlm.nih.gov/25406227/ DOI: 10.1177/0148607114558303","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-body growth and serum sodium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d0610d51-5037-5ea4-a35b-3dbaf7d140d3","evidence_kind":"source_excerpt","locator":"Lines 967-978","start_line":967,"end_line":978,"excerpt":"### sodium-preterm-sodium\nSupplemented preterm infants had fewer recorded serum sodium values below 135 mmol/L.\nCondition category: nutrient_deficiency\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Very premature infants can need a different sodium provision than older children or adults.\norganism: Human preterm infants\ntissue_or_cell_type: Whole-body growth and serum sodium\nexperimental_model: Randomized masked trial in 53 infants born before 32 weeks\nlimitations: Study regimen, not a dosing recommendation. Small neonatal trial; improved weight gain is not proof that every blood sodium measurement diagnoses total-body depletion.\nexposure: 4 mEq/kg/day supplemental sodium versus placebo, days 7–35\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/25406227.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a3c6cd28e4896dc8cdaeaacb7d524c55098b87dd5bf9d028ce49ba544832e339\", \"start_char\": 0, \"end_char\": 1645, \"text_sha256\": \"a3c6cd28e4896dc8cdaeaacb7d524c55098b87dd5bf9d028ce49ba544832e339\"}\n[sodium-p25406227] Impact of Early Sodium Supplementation on Hyponatremia and Growth in Premature Infants: A Randomized Controlled Trial. 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