{"id":"bb13313d-c971-546c-b3c9-eb7cee2c8c2e","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-raises-antioxidant-enzymes","predicate":"increases","statement":"(+)-Lariciresinol raised superoxide dismutase, glutathione peroxidase and catalase at transcript and protein level.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9c970882-eda4-50ee-93ce-a2ebe563047a","mechanism_event_label":"(+)-Lariciresinol raised superoxide dismutase, glutathione peroxidase and catalase at transcript and protein level.","subject":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"object":{"id":"19f2bdc0-4888-57d5-860f-119d5d478eb4","slug":"sod1","display_name":"Human copper-zinc superoxide dismutase / SOD1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"9c970882-eda4-50ee-93ce-a2ebe563047a","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-raises-antioxidant-enzymes-event","event_type":"observed_relationship","label":"(+)-Lariciresinol raised superoxide dismutase, glutathione peroxidase and catalase at transcript and protein level.","description":"(+)-Lariciresinol raised superoxide dismutase, glutathione peroxidase and catalase at transcript and protein level.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"19f2bdc0-4888-57d5-860f-119d5d478eb4","slug":"sod1","display_name":"Human copper-zinc superoxide dismutase / SOD1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e79d035c-0c02-5c0e-ac8f-d7fdeb663fbd","slug":"gpx1","display_name":"GPX1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6f9fc0e2-aa04-5701-b3d1-3c01ab37fcde","slug":"cat-catalase","display_name":"Catalase","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"(+)-Lariciresinol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression levels, not enzyme activity assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"(+)-Lariciresinol raised superoxide dismutase, glutathione peroxidase and catalase at transcript and protein level.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. (2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Antioxidant enzyme expression","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f332e5df-25cd-55b2-a93a-57cc678bbc22","evidence_kind":"source_excerpt","locator":"Lines 55-64","start_line":55,"end_line":64,"excerpt":"## plus-lariciresinol-raises-antioxidant-enzymes\n(+)-Lariciresinol raised superoxide dismutase, glutathione peroxidase and catalase at transcript and protein level.\nModel/species: RAW 264.7 murine macrophages\nTissue/system: Antioxidant enzyme expression\nExposure: (+)-Lariciresinol\nRoute: In vitro\nDuration: Not stated here\nLimits: Expression levels, not enzyme activity assays.\nPrimary reference: Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. (2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"48c58761-0291-5bad-a926-75e904b2d802","stable_key":"import-96d9034a-2550-5f3c-b767-1767c982533c","title":"Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"6bf0015b7ff727b7a80d693dd18ffdd227d0e16ae45d9e85a5f81fa733edd3a4","revision_id":"219d9b0c-1a71-5e27-8d6c-7b3e77a594c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}