{"id":"bb0b99b7-7e8b-5550-ad23-641f084eb2b4","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-iodine-context-lowers-tsh","predicate":"supplementation_reduces","statement":"Vitamin A without iodine supplementation lowered TSH in the iodine-deficient study setting.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e30f65fa-43c8-56e2-a451-b7feee2c01eb","mechanism_event_label":"Vitamin A status affected how strongly the thyroid was being stimulated.","subject":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"object":{"id":"b2450167-5a3a-5f1d-8933-8b46c25e9dff","slug":"serum-tsh-concentration","display_name":"Serum TSH concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e30f65fa-43c8-56e2-a451-b7feee2c01eb","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-iodine-context-lowers-tsh-event","event_type":"observed_intervention","label":"Vitamin A status affected how strongly the thyroid was being stimulated.","description":"Vitamin A without iodine supplementation lowered TSH in the iodine-deficient study setting.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"deficiency_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a9b31350-634e-519e-b31e-3f766dd6ae62","slug":"tshb","display_name":"Thyroid-stimulating hormone beta subunit","entity_type_key":"protein"},"role":"hormone_subunit_identity","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"62e3f5bd-503b-5ea8-b102-966aa3b7319c","slug":"retinyl-palmitate","display_name":"All-trans-retinyl palmitate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b2450167-5a3a-5f1d-8933-8b46c25e9dff","slug":"serum-tsh-concentration","display_name":"Serum TSH concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [va-zimmermann2007-iodine] Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate (2007). https://pubmed.ncbi.nlm.nih.gov/17921382/ DOI: 10.1093/ajcn/86.4.1040","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}