{"id":"baf17b85-de4c-599e-93c3-5dda17f8433d","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-senolysis-selectivity-null","predicate":"did_not_eliminate","statement":"Fisetin was not senolytic in the tested senescent human IMR90 fibroblasts or primary preadipocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4dbc5a59-9d7c-5331-92e2-b2c05acfcce0","mechanism_event_label":"Cell type and induction method limit the senolytic label.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"747f7d91-29df-59ef-bbd0-a2ffbdef4f5f","slug":"human-irradiated-imr90-preadipocyte-senescence","display_name":"Senescent human IMR90/preadipocyte viability in the irradiation study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4dbc5a59-9d7c-5331-92e2-b2c05acfcce0","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-senolysis-selectivity-null-event","event_type":"observed_relationship","label":"Cell type and induction method limit the senolytic label.","description":"Fisetin was not senolytic in the tested senescent human IMR90 fibroblasts or primary preadipocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"747f7d91-29df-59ef-bbd0-a2ffbdef4f5f","slug":"human-irradiated-imr90-preadipocyte-senescence","display_name":"Senescent human IMR90/preadipocyte viability in the irradiation study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same senolytic screening study as the HUVEC result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different cells and later etoposide models are not automatic scientific contradictions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cell type and induction method limit the senolytic label.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28273655/ · DOI 10.18632/aging.101202","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"00238954-77d2-5b80-abac-2da7c420bce3","evidence_kind":"source_excerpt","locator":"Lines 192-198","start_line":192,"end_line":198,"excerpt":"## fisetin-senolysis-selectivity-null\nCell type and induction method limit the senolytic label.\nFisetin was not senolytic in the tested senescent human IMR90 fibroblasts or primary preadipocytes.\nModel: Same senolytic screening study as the HUVEC result.\nLimitations: Different cells and later etoposide models are not automatic scientific contradictions.\nEvidence access: Primary abstract\nNew agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28273655/ · DOI 10.18632/aging.101202","model_system":"Same senolytic screening study as the HUVEC result.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}