{"id":"badf3c2d-8adc-5df9-b8e1-a49c1c40d1ac","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-glucose-closes-beta-channel","predicate":"inhibits-through-metabolism","statement":"Glucose metabolism closed resting potassium channels in cell-attached rat beta-cell recordings.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5d0de8ce-3f17-5caa-951c-7209109579f0","mechanism_event_label":"The glucose fuel signal reduced potassium conductance.","subject":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"object":{"id":"a4a6ce6c-ada1-5c56-8adf-d2bddf959383","slug":"beta-cell-katp-current","display_name":"Pancreatic beta-cell ATP-sensitive potassium current","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5d0de8ce-3f17-5caa-951c-7209109579f0","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-glucose-closes-beta-channel-event","event_type":"biochemical_relationship","label":"The glucose fuel signal reduced potassium conductance.","description":"Glucose metabolism closed resting potassium channels in cell-attached rat beta-cell recordings.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"conducted ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"724a20c7-a425-57fd-8aa0-8f5b08d9c049","slug":"kir6-2-sur1-katp-channel","display_name":"Kir6.2-SUR1 ATP-sensitive potassium channel","entity_type_key":"protein_complex"},"role":"modern canonical channel identity","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a4a6ce6c-ada1-5c56-8adf-d2bddf959383","slug":"beta-cell-katp-current","display_name":"Pancreatic beta-cell ATP-sensitive potassium current","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Carbohydrate metabolism regulates a potassium conductance rather than proving potassium supplementation benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-attached patch recordings in isolated rat pancreatic beta cells; glucose and metabolism perturbation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The experiment does not establish dietary potassium control of insulin secretion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The glucose fuel signal reduced potassium conductance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ashcroft-1984-glucose] Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells (1984). https://www.nature.com/articles/312446a0 DOI: 10.1038/312446a0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Pancreatic beta cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8542d571-34d8-547d-bb81-f2031067b20b","evidence_kind":"source_excerpt","locator":"Lines 774-784","start_line":774,"end_line":784,"excerpt":"### k-glucose-closes-beta-channel\nGlucose metabolism closed resting potassium channels in cell-attached rat beta-cell recordings.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The glucose fuel signal reduced potassium conductance.\norganism: Rat\ntissue_or_cell_type: Pancreatic beta cells\nexperimental_model: Cell-attached patch recordings in isolated rat pancreatic beta cells; glucose and metabolism perturbation.\nlimitations: The experiment does not establish dietary potassium control of insulin secretion.\ncross_nutrient: Carbohydrate metabolism regulates a potassium conductance rather than proving potassium supplementation benefit.\n[ashcroft-1984-glucose] Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells (1984). https://www.nature.com/articles/312446a0 DOI: 10.1038/312446a0","model_system":"Cell-attached patch recordings in isolated rat pancreatic beta cells; glucose and metabolism perturbation.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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