{"id":"bab554d7-bcea-5b1f-9439-527e1ae336bb","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-ca24","predicate":"increases","statement":"Later nighttime conservation did not fully offset earlier loss; net 24-hour urinary excretion increased by 0.32 mmol.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"46be6084-b548-536e-b7d4-5ff160ba409e","mechanism_event_label":"Later compensation reduced, but did not erase, the measured daily loss.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"538fbe5c-11da-5aa5-990f-e8be1aa7bc5a","slug":"urinary-calcium-excretion","display_name":"Urinary calcium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"46be6084-b548-536e-b7d4-5ff160ba409e","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-ca24-event","event_type":"observed_relationship","label":"Later compensation reduced, but did not erase, the measured daily loss.","description":"Later nighttime conservation did not fully offset earlier loss; net 24-hour urinary excretion increased by 0.32 mmol.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"538fbe5c-11da-5aa5-990f-e8be1aa7bc5a","slug":"urinary-calcium-excretion","display_name":"Urinary calcium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"17 adults; controlled diet; two 3 mg/kg lean-body-mass doses on day two of a before/after metabolic-ward trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Two-day urinary balance is not total body mineral balance or a long-term deficiency diagnosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Later compensation reduced, but did not erase, the measured daily loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of caffeine on circadian excretion of urinary calcium and magnesium. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7836625/ · DOI 10.1080/07315724.1994.10718436","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"eac6bf78-25e6-550b-828b-ba50af39910e","evidence_kind":"source_excerpt","locator":"Lines 340-346","start_line":340,"end_line":346,"excerpt":"## caf-ca24\nLater compensation reduced, but did not erase, the measured daily loss.\nLater nighttime conservation did not fully offset earlier loss; net 24-hour urinary excretion increased by 0.32 mmol.\nModel: 17 adults; controlled diet; two 3 mg/kg lean-body-mass doses on day two of a before/after metabolic-ward trial.\nLimitations: Two-day urinary balance is not total body mineral balance or a long-term deficiency diagnosis.\nEvidence access: Primary abstract\nEffect of caffeine on circadian excretion of urinary calcium and magnesium. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7836625/ · DOI 10.1080/07315724.1994.10718436","model_system":"17 adults; controlled diet; two 3 mg/kg lean-body-mass doses on day two of a before/after metabolic-ward trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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