{"id":"ba9cbdef-04b7-574a-91c4-a67976f4f4bc","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-slc7a11-expression","predicate":"increases_expression","statement":"At 5 micromolar, luteolin increased SLC7A11 expression in CCl4-challenged human HepG2 cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"498fb159-7725-55be-8401-27d56de54f95","mechanism_event_label":"Cystine-handling machinery responded in an injury model.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"aac19cc3-1b68-5ca3-a896-f61184f7320a","slug":"slc7a11","display_name":"SLC7A11","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"498fb159-7725-55be-8401-27d56de54f95","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-slc7a11-expression-event","event_type":"observed_relationship","label":"Cystine-handling machinery responded in an injury model.","description":"At 5 micromolar, luteolin increased SLC7A11 expression in CCl4-challenged human HepG2 cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aac19cc3-1b68-5ca3-a896-f61184f7320a","slug":"slc7a11","display_name":"SLC7A11","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HepG2 culture, 3.5 mM CCl4.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not direct binding, transporter flux, or normal human-liver exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cystine-handling machinery responded in an injury model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38755566/ · DOI 10.1186/s12906-024-04486-2","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"46db8ed8-49fa-5648-bcb4-a09f6e519d93","evidence_kind":"source_excerpt","locator":"Lines 516-522","start_line":516,"end_line":522,"excerpt":"## luteolin-slc7a11-expression\nCystine-handling machinery responded in an injury model.\nAt 5 micromolar, luteolin increased SLC7A11 expression in CCl4-challenged human HepG2 cells.\nModel: HepG2 culture, 3.5 mM CCl4.\nLimitations: Not direct binding, transporter flux, or normal human-liver exposure.\nEvidence access: Primary full text\nLuteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38755566/ · DOI 10.1186/s12906-024-04486-2","model_system":"HepG2 culture, 3.5 mM CCl4.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}