{"id":"ba938b42-ccad-5fb0-b016-91867d9be092","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-milk-infant-marker-response","predicate":"maternal_supplementation_accompanied_better_infant_marker","statement":"Infants of supplemented mothers had lower activation coefficients; maternal and infant values rose toward placebo levels after supplement withdrawal.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a476398b-aac5-5467-911c-7417bee3a4dc","mechanism_event_label":"The infant marker improved while maternal B2 was supplied and worsened again after it stopped.","subject":{"id":"2c873cdc-eb26-596b-a96d-b212e1ef56a8","slug":"human-milk-riboflavin-concentration","display_name":"Human milk riboflavin concentration","entity_type_key":"cellular_process"},"object":{"id":"34eee5dc-1157-5374-8f5c-ce7ec87156a4","slug":"erythrocyte-glutathione-reductase-activation-coefficient","display_name":"Erythrocyte glutathione reductase activation coefficient / EGRAC","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a476398b-aac5-5467-911c-7417bee3a4dc","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-milk-infant-marker-response-event","event_type":"observed_intervention","label":"The infant marker improved while maternal B2 was supplied and worsened again after it stopped.","description":"Infants of supplemented mothers had lower activation coefficients; maternal and infant values rose toward placebo levels after supplement withdrawal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"maternal_intervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ae04c12f-c0ac-5c8d-9ee2-76e58156d105","slug":"gsr","display_name":"Glutathione reductase / GSR","entity_type_key":"protein"},"role":"assay_enzyme","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2c873cdc-eb26-596b-a96d-b212e1ef56a8","slug":"human-milk-riboflavin-concentration","display_name":"Human milk riboflavin concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"34eee5dc-1157-5374-8f5c-ce7ec87156a4","slug":"erythrocyte-glutathione-reductase-activation-coefficient","display_name":"Erythrocyte glutathione reductase activation coefficient / EGRAC","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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unverified.","entity":null}],"evidence":[{"id":"0924576c-2f84-55e8-82b0-5d8f58ce4b58","evidence_kind":"source_excerpt","locator":"Lines 1777-1787","start_line":1777,"end_line":1787,"excerpt":"### b2-milk-infant-marker-response\nInfants of supplemented mothers had lower activation coefficients; maternal and infant values rose toward placebo levels after supplement withdrawal.\nCondition category: nutrient_deficiency\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The infant marker improved while maternal B2 was supplied and worsened again after it stopped.\norganism: Homo sapiens\ntissue_or_cell_type: Infant erythrocytes in maternal lactation trial\nexperimental_model: Double-blind controlled trial in 60 lactating women from two Gambian villages and their infants.\nlimitations: Supports maternal-infant supply responsiveness; not proof of a developmental benefit or an independently measured transport mechanism.\nexposure: Maternal 2 mg/day riboflavin or placebo for 12 weeks; background intake about 0.5 mg/day; supplementation-withdrawal observations.\n[b2-bates1982] Riboflavin requirements of lactating Gambian women: a controlled supplementation trial (1982). https://pubmed.ncbi.nlm.nih.gov/7072623/ DOI: 10.1093/ajcn/35.4.701","model_system":"Double-blind controlled trial in 60 lactating women from two Gambian villages and their infants.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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