{"id":"ba8492d8-8517-5795-bf28-7e78a1c1da50","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:bromocriptine","predicate":"decreases_in_recorded_experiment","statement":"Bromocriptine lowered thymulin activity in mice and concurrent prolactin restored it.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b758edbb-a23b-5951-ab1a-e249dfbba4a5","mechanism_event_label":"Bromocriptine lowered thymulin activity in mice and concurrent prolactin restored it.","subject":{"id":"fffd8d81-70de-58de-b48a-49aba0b70a1f","slug":"bromocriptine","display_name":"Bromocriptine","entity_type_key":"drug"},"object":{"id":"8cf03312-bba2-5625-b1ad-abc85d7bddc5","slug":"mouse-thymulin-bioactivity","display_name":"Mouse thymulin bioassay activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b758edbb-a23b-5951-ab1a-e249dfbba4a5","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:bromocriptine-event","event_type":"experimental_observation","label":"Bromocriptine lowered thymulin activity in mice and concurrent prolactin restored it.","description":"| Prolactin | Increased thymulin secretion in human/mouse TEC cultures. In mice, prolactin increased activity; bromocriptine lowered it, and concurrent prolactin restored it. This is an experimental hormone/drug interaction, not proof that every bromocriptine-treated person develops thymulin deficiency. [1989 study](https://pubmed.ncbi.nlm.nih.gov/2737149/) |","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fffd8d81-70de-58de-b48a-49aba0b70a1f","slug":"bromocriptine","display_name":"Bromocriptine","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Bromocriptine","sequence_order":0,"notes":""},{"entity":{"id":"8cf03312-bba2-5625-b1ad-abc85d7bddc5","slug":"mouse-thymulin-bioactivity","display_name":"Mouse thymulin bioassay activity","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""},{"entity":{"id":"da232e57-9493-5b81-8701-0faf4218db46","slug":"prolactin","display_name":"Prolactin","entity_type_key":"peptide"},"role":"rescue intervention","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"role":"bioassayed peptide","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Bromocriptine\", \"comparator\": \"Control or concurrent prolactin rescue\", \"endpoint\": \"Bromocriptine lowered thymulin activity in mice and concurrent prolactin restored it.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Mouse endocrine manipulation; not an established human drug-induced deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Bromocriptine lowered thymulin activity in mice and concurrent prolactin restored it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Neuroendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells. | 1989 | DOI 10.1210/endo-125-1-3 | PMID 2737149 | https://pubmed.ncbi.nlm.nih.gov/2737149/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 92-92; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"92ae2916-0bf0-5b5d-9eb0-984addd6e0f7","evidence_kind":"source_excerpt","locator":"Lines 92-92","start_line":92,"end_line":92,"excerpt":"| Prolactin | Increased thymulin secretion in human/mouse TEC cultures. In mice, prolactin increased activity; bromocriptine lowered it, and concurrent prolactin restored it. This is an experimental hormone/drug interaction, not proof that every bromocriptine-treated person develops thymulin deficiency. 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