{"id":"ba73ac1e-0873-50d4-8b1e-c220fa68427d","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-cox-functions","predicate":"inhibits","statement":"Resveratrol inhibited cyclooxygenase and hydroperoxidase functions in the original chemoprevention assay program.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"04d5d8ff-4aaa-5cb2-a14c-50b9ff03fd60","mechanism_event_label":"Inflammatory lipid-enzyme chemistry was an early experimental branch.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"bfee7d99-df07-59c2-bf6b-c24fb3d41a59","slug":"jang-cyclooxygenase-hydroperoxidase-functions","display_name":"Cyclooxygenase/hydroperoxidase activities in Jang 1997","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"04d5d8ff-4aaa-5cb2-a14c-50b9ff03fd60","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-cox-functions-event","event_type":"observed_relationship","label":"Inflammatory lipid-enzyme chemistry was an early experimental branch.","description":"Resveratrol inhibited cyclooxygenase and hydroperoxidase functions in the original chemoprevention assay program.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bfee7d99-df07-59c2-bf6b-c24fb3d41a59","slug":"jang-cyclooxygenase-hydroperoxidase-functions","display_name":"Cyclooxygenase/hydroperoxidase activities in Jang 1997","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Biochemical assays accompanying cell, mammary-organ and mouse-skin experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract does not resolve every enzyme isoform; not a clinical anticancer claim.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Inflammatory lipid-enzyme chemistry was an early experimental branch.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. · 1997 · https://pubmed.ncbi.nlm.nih.gov/8985016/ · DOI 10.1126/science.275.5297.218","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cc4d0b20-0584-5baf-a542-5c3109581333","evidence_kind":"source_excerpt","locator":"Lines 526-532","start_line":526,"end_line":532,"excerpt":"## resveratrol-cox-functions\nInflammatory lipid-enzyme chemistry was an early experimental branch.\nResveratrol inhibited cyclooxygenase and hydroperoxidase functions in the original chemoprevention assay program.\nModel: Biochemical assays accompanying cell, mammary-organ and mouse-skin experiments.\nLimitations: Abstract does not resolve every enzyme isoform; not a clinical anticancer claim.\nEvidence access: Primary abstract\nCancer chemopreventive activity of resveratrol, a natural product derived from grapes. · 1997 · https://pubmed.ncbi.nlm.nih.gov/8985016/ · DOI 10.1126/science.275.5297.218","model_system":"Biochemical assays accompanying cell, mammary-organ and mouse-skin experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}